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Recent neuroimaging studies have reported abnormal functional connectivity of the anterior insula to various limbic, salience, and motor regions in smaller samples of misophonic individuals versus controls, suggesting potential differences in underlying attentional or emotional processes. These findings prompt questions about the insular connectivity profile in larger samples of adults, what patterns emerge when the samples span a wider range of misophonia severity, and how these patterns may or may not overlap with other co\u2010occurring disorders. To address these questions, we analyzed resting\u2010state functional magnetic resonance imaging data from the open Welsh Advanced Neuroimaging Database (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009162) comprising participants recruited from the general adult population and assessed for sensory sensitivity, anxiety, depression, and autistic traits. A misophonia severity score was derived from the sensory sensitivity data using a model trained on a second adult self\u2010report sample from Oklahoma (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009777). Using anterior insula as a seed for a whole\u2010brain seed\u2010to\u2010voxel connectivity analysis, the derived misophonia severity scores were found to be significantly related to connectivity from the insula to clusters overlapping the planum temporale, operculum, precentral gyrus, and supplementary motor area. Notably, this insular connectivity profile was unique to the anterior insula of the salience network and was not observed when dividing the sample into misophonia (patient) versus control groups, or when grouping participants as a function of anxiety, depression, or autistic traits. These results underline the importance of the salience\u2010network anterior insula in understanding misophonic aversion and provide tentative evidence of neurological differences between misophonia and anxiety, depression, and autism. This work aids in our understanding of neural mechanisms of misophonia and emphasizes the benefit of treating misophonia as a continuous spectrum disorder to better reflect the variability of symptoms in the real world.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70468","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:45:29Z","timestamp":1770896729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Selective Disruption of Salience\u2010Network Anterior Insula Connectivity in Misophonia: A Disorder\u2010Specific Neural Signature"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-2516","authenticated-orcid":false,"given":"Heather A.","family":"Hansen","sequence":"first","affiliation":[{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Psychological Sciences William &amp; Mary  Williamsburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Oklahoma  Norman Oklahoma USA"},{"name":"Department of Pediatrics Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-6882","authenticated-orcid":false,"given":"Catherine M.","family":"Bain","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Ethridge","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Oklahoma  Norman Oklahoma USA"},{"name":"Department of Pediatrics, Section of Developmental and Behavioral Pediatrics University of Oklahoma Health  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-6808","authenticated-orcid":false,"given":"Christine L.","family":"Tardif","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology &amp; Neurosurgery McGill University  Montreal Quebec Canada"},{"name":"Department of Biomedical Engineering McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.23552"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0746"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2024.1361645"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2022.11.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171200147X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-019-04180-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2023.0257"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.177"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0974"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.55.1.75"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.519681"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.048"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.090"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.37708\/psyct.v13i2.454"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2018.06.004"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08121894"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000904"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7080108"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001163-199704000-00005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010025\u201006924\u20107"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20688"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2019.1609086"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/20473869.2023.2165231"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2024.108842"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2025.101560"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02191-4"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.827998"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263230"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.23196"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.880759"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0299698"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1073-0"},{"key":"e_1_2_11_37_1","first-page":"1","article-title":"Glutamatergic and Resting\u2010State Functional Connectivity Correlates of Severity in Major Depression\u2014The Role of Pregenual Anterior Cingulate Cortex and Anterior Insula","volume":"4","author":"Horn D. 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