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However, variation in PET scanner technology can lead to misinterpretation and quantification errors with mismatched atlases. This study aimed to develop high\u2010resolution, age\u2010stratified FDG brain atlases harmonized across different effective image resolutions (EIRs) to support diverse PET\/CT scanners. A total of 140 adults (aged 20\u201390\u2009years, 72 males) were retrospectively enrolled and divided into seven age groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920). All underwent\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG PET\/CT at China\u2010Japan Friendship Hospital (Jan 2022\u2010May 2023) using the Siemens Biograph Vision 600 scanner. PET scans (4\u2009min) were acquired 60\u2009min after\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG injection (4.44\u2009MBq\/kg). System EIR was measured using a Hoffman phantom, and images were smoothed to emulate 5.0\u20136.0\u2009mm and 8.0\u201310.0\u2009mm resolutions. Images were normalized to MNI space (1.0\u2009mm) via ANTs, and subjects with outlier FDG uptake values were excluded. SUVRs were calculated using the whole cerebellum as reference. Age\u2010stratified and EIR\u2010harmonized atlases were created. Gray\/white contrast (GWC), age correlations, and SUVR differences were analyzed. After quality control, 97 participants were included for atlas construction. Atlases for both EIRs were generated. GWC was higher at 5.0\u20136.0\u2009mm than at 8.0\u201310.0\u2009mm (e.g., 2.73 vs. 1.76 in 20\u201330\u2009years). SUVRs in cortical and subcortical regions negatively correlated with age; brainstem SUVRs correlated only at lower resolution. SUVRs were higher at high resolution across regions. A set of age\u2010dependent, harmonized FDG\u2010PET atlases was developed and the quantitative metrics across age were characterized.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70502","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:00:28Z","timestamp":1773136828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Generation of an Age\u2010Dependent and Harmonized\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    \u2010\n                    <scp>FDG<\/scp>\n                    Brain\n                    <scp>PET<\/scp>\n                    Atlas Using a High\u2010Sensitivity Short\u2010Axial\n                    <scp>FOV PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    System"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4319-0537","authenticated-orcid":false,"given":"Yidan","family":"Wei","sequence":"first","affiliation":[{"name":"China\u2010Japan Friendship Institute of Clinical Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Beijing Hospital of Traditional Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8122-6268","authenticated-orcid":false,"given":"Lijie","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine China\u2010Japan Friendship Hospital, Yinghua East Road Hepingli  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine China\u2010Japan Friendship Hospital, Yinghua East Road Hepingli  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine China\u2010Japan Friendship Hospital, Yinghua East Road Hepingli  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology China\u2010Japan Friendship Hospital, Yinghua East Road Hepingli  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine China\u2010Japan Friendship Hospital, Yinghua East Road Hepingli  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149\u2010015\u20101024\u20100"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2830\u201016.2016"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26119"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010014\u20109235\u20104"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.18153"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2024.09.007"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010021\u201005603\u2010w"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1208"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010018\u20104207\u20109"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.931536"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201057313\u2010x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.263194"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010025\u201007211\u20104"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010023\u201006152\u20100"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.782738"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658\u2010023\u201000588\u2010x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.035774"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.713680"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010011\u20101745\u20109"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201087564\u20106"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550\u2010021\u201000771\u20100"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597\u2010021\u201001089\u20101"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010022\u201005752\u20106"}],"container-title":["Human 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