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cognitive processes, such as language and visuo\u2010spatial reasoning. Although studies of white matter asymmetry have been previously documented, they have often been constrained by limited age ranges, sample sizes, or the scope of the tracts and structural features examined. While normative lifespan charts for brain structures are emerging, comprehensive charts detailing white matter asymmetries across numerous pathways and diverse structural measures have been notably absent. This study addresses this gap by leveraging a large\u2010scale dataset of 35,120 typically developing and aging individuals, ranging from 0 to 100\u2009years of age, from 50 primary neuroimaging studies. We generated comprehensive lifespan trajectories for 30 lateralized association and projection white matter tracts, examining six distinct microstructural and macrostructural features of these pathways. Our findings reveal that: (1) asymmetries are widespread across the brain's white matter and are present in all 30 pathways; (2) for a given pathway, the degree and direction of asymmetry differ between features of tissue microstructure and pathway macrostructure; (3) asymmetries vary across and within pathway types (association and projection tracts); and (4) these asymmetries are not static, following unique trajectories across the lifespan, with distinct changes during development, and a general trend of becoming more asymmetric with increasing age (particularly in later adulthood) across pathways. This study represents the most extensive characterization of white matter asymmetry across the lifespan to date, charting how lateralization patterns emerge, mature, and change throughout life. It provides a foundational resource for understanding the principles of white matter organization from early to late life, its relation to functional specialization and inter\u2010individual variability, and offers a key reference for interpreting deviations during healthy development and aging as well as those associated with clinical populations.<\/jats:p>","DOI":"10.1002\/hbm.70519","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:20:14Z","timestamp":1780734014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lifespan Trajectories of Asymmetry in White Matter Tracts"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7766-4217","authenticated-orcid":false,"given":"Sam","family":"Bogdanov","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program Vanderbilt University  Nashville Tennessee 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