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Entropy maps indicate the extent to which the network communities present in a local area are ordered or disordered. We demonstrate how spatial entropy can be quantified for each voxel in the brain according to the network community affiliations of surrounding voxels. This process results in interpretable maps of brain network entropy. We show that local entropy decreases in predictable brain regions during working memory and music\u2010listening tasks. We suggest that these regional entropy reductions reflect self\u2010organization of neural processes in support of functionally localized cognitive tasks. In summary, we propose a method that allows group\u2010level comparison of the brain network community structure identified in individuals. Analyses in this work provide a framework for future analyses of spatial entropy in complex networks that can be mapped to Euclidean space\u2014both within the brain and in other contexts.<\/jats:p>","DOI":"10.1002\/hbm.70525","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:25:28Z","timestamp":1775629528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatial Entropy of Brain Network Landscapes: A Novel Method to Assess Spatial Disorder in Brain Networks"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-9453","authenticated-orcid":false,"given":"Clayton C.","family":"McIntyre","sequence":"first","affiliation":[{"name":"Wake Forest Graduate School of Arts and Sciences Neuroscience Graduate Program  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2440-8055","authenticated-orcid":false,"given":"Shannon M.","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Wake Forest Graduate School of Arts and Sciences Neuroscience Graduate Program  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Khodaei","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Sciences Virginia Tech\u2010Wake Forest University  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Lyday","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan H.","family":"Burdette","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Laurienti","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2010.00147"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/e25121634"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018985108"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-4632.1974.tb01014.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0480"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/e23020232"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510619112"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/11556114_14"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2965\u201015.2016"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.055"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903215107"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/378279a0"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000381"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4135"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.011"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00880"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.051"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00090"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160214"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","unstructured":"McIntyre C. 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