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In parallel, dynamic functional network connectivity (dFNC) has shown high sensitivity to brain changes related to mental disorders. However, previous studies linking dFNC to genetics largely follow a paradigm to identify associations between one set of genetic factors and multiple sets of connectivity features from different dFNC states, ignoring the potential variability in genetic correlates across states. We propose a novel joint ICA (jICA)\u2010based \u201cdynamic fusion\u201d framework to identify dynamically tuned genetic manifolds. A sliding window approach was utilized to estimate four dFNC states and compute subject\u2010level state\u2010average dFNC (sa\u2010dFNC) features. The sa\u2010dFNC features of each state were combined with schizophrenia risk single nucleotide polymorphisms (SNPs) within a jICA fusion framework, resulting in four parallel fusions in 32,861 individuals of the UK Biobank cohort. The extracted four sets of joint SNP\u2010dFNC components were further validated for clinical relevance in a combined schizophrenia cohort of 820 individuals (348 patients). The similarity of SNP\u2010dFNC components across four parallel fusions was evaluated as a measure of state variability. We observed a mixture of \u201cstate\u2010invariant\u201d and \u201cstate\u2010variant\u201d components for SNP and dFNC modalities. Particularly, the schizophrenia\u2010related state\u2010variant SNP components, or manifolds, complemented each other by capturing different SNPs involved in the same biological functions, revealing a partition of genomic risk particularly elicited by the dynamics of brain function. By augmenting the SNP factors to state\u2010variant manifolds, this dynamic fusion framework promises additional insights into the underlying genetic risk of disease\u2010related alterations in dynamic brain function.<\/jats:p>","DOI":"10.1002\/hbm.70530","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:56:28Z","timestamp":1776743788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic Fusion of Genomics and Functional Network Connectivity in\n                    <scp>UK<\/scp>\n                    Biobank Reveals Schizophrenia\u2010Related\n                    <scp>SNP<\/scp>\n                    Manifolds"],"prefix":"10.1002","volume":"47","author":[{"given":"Jiayu","family":"Chen","sequence":"first","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University)  Atlanta Georgia USA"},{"name":"Department of Computer Science Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Iraji","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University)  Atlanta Georgia USA"},{"name":"Department of Computer Science Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zening","family":"Fu","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University)  Atlanta Georgia USA"},{"name":"Department of Computer Science Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-2225","authenticated-orcid":false,"given":"Marlena","family":"Duda","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University)  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Andr\u00e9s\u2010Camaz\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, IiSGM  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishal","family":"Thapaliya","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University)  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University)  Atlanta Georgia USA"},{"name":"Department of Computer Science Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vince D.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University)  Atlanta Georgia USA"},{"name":"Department of Computer Science Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.09.020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010017\u20109338\u20109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674379704200104"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9985"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8757"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.86"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1995.7.6.1129"},{"key":"e_1_2_10_10_1","first-page":"374","article-title":"Synapse Pathology in Schizophrenia: A Meta\u2010Analysis of Postsynaptic Elements in 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