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SUDs are well established in taxonomies of mental\u2010health disorders. BAs are only recently recognized as mental\u2010health disorders, with limited and conflicting categorizations. Within each category, individual diagnoses are based on objects of addiction. Despite addiction prevalence, no comprehensive coordinate\u2010based meta\u2010analysis (CBMA) has examined both SUD and BA. The overall goal of this study was to identify GM alterations associated with SUD and BA, both independently and jointly. To this end, a total of 108 peer\u2010reviewed VBM studies reporting case\u2013control contrasts in addiction disorders were identified: 83 reports across five SUD diagnoses (8206 participants); and 25 BA reports across two diagnoses (1572 participants). On these datasets, eight transdiagnostic alteration likelihood estimation (ALE) CBMAs were performed. Three primary ALEs computed cross\u2010study neuroanatomical convergence for: (1) SUD; (2) BA; and (3) Pooled Addictions (SUD\u2009+\u2009BA). These three primary ALEs were supplemented by five ALE\u2010to\u2010ALE comparison analyses: interaction (SUD\u2009+\u2009BA to SUD and BA), overlap (SUD on BA), conjunction (SUD on BA), and contrast (SUD &gt; BA; BA &gt; SUD). The independently performed ALEs demonstrated largely distinct anatomical\u2010alteration patterns, overlapping only in the caudate nucleus. The pooled ALE, however, yielded many (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924\/34) alteration foci not identified in either independent ALE. All newly emerging foci were contributed to by both conditions (SUD and BA) and thus termed \u201cinteractive.\u201d Functional decoding of all three ALEs consistently identified reward and reward\u2010related cognitive operations as being performed by the brain\u2010regions exhibiting structural alterations in addiction disorders.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70551","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:23:41Z","timestamp":1784031821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Structural Abnormalities in Addiction Disorders: Transdiagnostic Meta\u2010Analyses"],"prefix":"10.1002","volume":"47","author":[{"given":"Duaa M.","family":"Banaja","sequence":"first","affiliation":[{"name":"Radiologic Sciences, Faculty of Applied Medical Sciences King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9788-8058","authenticated-orcid":false,"given":"Enrique","family":"Torres Hernandez","sequence":"additional","affiliation":[{"name":"Research Imaging Institute University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal G.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Research Imaging Institute University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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