{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:10:58Z","timestamp":1781532658983,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["2016000021223TD07"],"award-info":[{"award-number":["2016000021223TD07"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quantitative MR relaxometry provides sensitive and reproducible measures of brain microstructure and is increasingly used in studies of ageing and neurodegenerative disease. However, normative brain atlases covering the adult lifespan remain scarce, especially from large, harmonized, multicenter datasets. This study aimed to establish lifespan\u2010based normative\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    and\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    atlases to support individualized assessment and group\u2010level comparisons. We retrospectively analyzed 947 healthy Han Chinese adults (421 males; median age 39\u2009years; range 19\u201372) from 11 imaging centers in China.\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    and\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    maps were acquired with harmonized MP2RAGE and GRAPPATINI protocols, processed using a unified pipeline, and modeled with voxelwise mixed\u2010effects regression including linear and quadratic age terms, sex, and random intercepts for site. Intersite reproducibility was further evaluated in three traveling subjects scanned at all centers. The atlases demonstrated region\u2010specific age and sex effects in both white and gray matter. Intersite variability was minimal (intraclass correlation coefficients &gt;\u20090.99 for\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    and &gt;\u20090.90 for\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    ). Both\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    and\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    followed quadratic trajectories, decreasing in early adulthood, reaching minima in midlife, and increasing in later decades, with the strongest effects in cortical gray matter. Sex differences were most pronounced in parietal and callosal regions. These lifespan\u2010based normative relaxometry atlases provide high\u2010fidelity references for age\u2010 and sex\u2010related microstructural changes in the healthy brain. They provide quantitative benchmarks for individualized profiling and group comparisons in Chinese adult populations, while validation in other ethnic populations remains necessary before broader application.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70555","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:57:09Z","timestamp":1780055829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Normative\n                    <i>T<\/i>\n                    <sub>1<\/sub>\n                    and\n                    <i>T<\/i>\n                    <sub>2<\/sub>\n                    Brain Atlases Across the Adult Lifespan in a Chinese Cohort: Multicenter Quantitative\n                    <scp>MRI<\/scp>\n                    Benchmarks for Ageing and Neurodegenerative Research"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0013-878X","authenticated-orcid":false,"given":"Junjie","family":"Wang","sequence":"first","affiliation":[{"name":"School of Psychology Capital Normal University, Beijing Key Laboratory of Learning and Cognition  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-6634","authenticated-orcid":false,"given":"Gian Franco","family":"Piredda","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hilbert","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG  Lausanne Switzerland"},{"name":"Department of Radiology Lausanne University Hospital and University of Lausanne  Lausanne 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Healthcare  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"MR Collaboration NE Asia, Siemens Healthcare  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipeng","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Psychology Capital Normal University, Beijing Key Laboratory of Learning and Cognition  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-9456","authenticated-orcid":false,"given":"Tobias","family":"Kober","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG  Lausanne Switzerland"},{"name":"Department of Radiology Lausanne University Hospital and University of Lausanne  Lausanne 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