{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:45:56Z","timestamp":1791776756621,"version":"4.3.4"},"reference-count":78,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Benzodiazepines act as positive allosteric modulators of the GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor and affect several motor and cognitive functions. By engaging perceptual\u2010motor as well as inhibitory control processes, the antisaccade task was used in previous studies to investigate effects of benzodiazepines on behavioral performance. Using a randomized, double\u2010blind, placebo\u2010controlled within\u2010subjects design, this study combined eye\u2010tracking with BOLD fMRI in order to examine the neural correlates of these effects for the first time.\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200939 healthy participants completed an antisaccade task after administration of either 1\u2009mg lorazepam or placebo. On a behavioral level, lorazepam led to reduced (anti\u2010)saccadic peak velocity as well as increased (anti\u2010)saccadic latency. On a neural level, drug\u2010induced reduction of BOLD was found in a fronto\u2010parietal\u2010occipital network, including key oculomotor regions. This result was further supported by our finding of increased GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor density in the affected network. On an individual level, decline in peak velocity under lorazepam was associated with decreased neural activation in several cortical regions, including medial frontal eye fields. No interactions between drug and saccade condition (prosaccade, antisaccade) were found. Our results therefore suggest GABAergic modulation of a more general saccade\u2010related network rather than of specific components for inhibitory control processes. Future studies may rely on BOLD signal as a sensitive marker for benzodiazepine activity during saccadic eye movements.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70598","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:42:14Z","timestamp":1783320134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>GABAergic<\/scp>\n                    Modulation of Brain Function During Prosaccade and Antisaccade Eye Movements: Evidence From Ultra\u2010High\u2010Field\n                    <scp>fMRI<\/scp>"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0141-6018","authenticated-orcid":false,"given":"Paulina","family":"Quint","sequence":"first","affiliation":[{"name":"Department of Psychology University of Bonn  Bonn 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