{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:25:54Z","timestamp":1786951554121,"version":"build-2736575974"},"reference-count":105,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471952"],"award-info":[{"award-number":["82471952"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371928"],"award-info":[{"award-number":["82371928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085MH277"],"award-info":[{"award-number":["2308085MH277"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Major depressive disorder (MDD) has been increasingly characterized as a network dysconnectivity syndrome. Although single\u2010subject morphological networks are advantageous in studying the brain connectome, extant research on MDD is limited by either small samples or a lack of integration of multi\u2010feature across different morphological features. We used the largest structural MRI data from 1442 MDD patients and 1277 controls to construct individual\u2010level cortical morphological networks based on cortical thickness (CT), cortical volume (CV), surface area (SA), and sulcal depth (SD). Group comparisons in interregional morphological connectivity (MC) and graph\u2010theoretical nodal properties were performed. Furthermore, support vector machine (SVM) was applied to evaluate whether the network alterations could distinguish patients from controls. As a result, MDD patients presented widespread alterations in MC, with distinct alteration patterns observed across four morphological networks. Specifically, CT\u2010based networks exhibited reduced MC primarily within and between higher\u2010order networks involving the default mode and frontoparietal networks, whereas CV\u2010based networks showed increased MC predominantly within the default mode network. By contrast, both SA\u2010 and SD\u2010based networks demonstrated enhanced MC mainly within and between lower\u2010order networks implicating the somatomotor and visual networks. Similar patterns of MC alterations were observed in first\u2010episode, drug\u2010naive MDD patients. Concurrently, nodal property analysis revealed increased betweenness centrality in multiple cortical regions in MDD. Moreover, SVM models based on the altered MC achieved moderate\u2010to\u2010good classification performance in distinguishing patients from controls. Overall, our findings of individual\u2010level morphological network alterations in depressed patients may corroborate the dysconnectivity hypothesis of MDD and could further inform its more accurate diagnosis.<\/jats:p>","DOI":"10.1002\/hbm.70612","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:47:51Z","timestamp":1784890071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Cortical Morphological Brain Networks and Their Diagnostic Classification Utility in Major Depressive Disorder"],"prefix":"10.1002","volume":"47","author":[{"given":"Xuetian","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Research Center of Clinical Medical Imaging, Anhui Province  Hefei China"},{"name":"Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Research Center of Clinical Medical Imaging, Anhui Province  Hefei China"},{"name":"Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology, Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology, Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Ying","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology, Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Han","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology, Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ping","family":"Cao","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan\u2010Mao","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Shan","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, the First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou 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of Cognitive Science and Mental Health Institute of Psychology, Chinese Academy of Sciences  Beijing China"},{"name":"Sino\u2010Danish College University of Chinese Academy of Sciences  Beijing China"},{"name":"Sino\u2010Danish Center for Education and Research Graduate University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Long","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, and National Clinical Research Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology, Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing 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of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Nan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Suzhou Psychiatric Hospital The Affiliated Guangji Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-2252","authenticated-orcid":false,"given":"Li","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Xijing Hospital of Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Anding 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Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-4177","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology, Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Xi'an Central Hospital  Xi'an 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