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In this 7T\u2010fMRI study we compared three methods of improving sensitivity in these areas: parallel transmit, which uses multiple transmit elements, controlled independently, to homogenise the flip angle experienced by the tissue; multi\u2010echo, which entails collection of multiple volumes at different echo times following a single radiofrequency pulse; and multiband, in which multiple slices are acquired simultaneously. We found that parallel transmit and multi\u2010echo increased the magnitude of the BOLD signal change, but only multi\u2010echo increased BOLD magnitude in areas prone to susceptibility artefacts. Multiband and denoising of multi\u2010echo data with independent components analysis (ICA) both improved precision of GLM fit. Exploratory results suggested that multi\u2010echo and ICA denoising can both benefit multivariate analyses. In conclusion, a multi\u2010echo, multiband sequence improved fMRI quality in areas prone to susceptibility artefacts while maintaining sensitivity across the whole brain. We recommend this approach for studies investigating the functional roles of ventral temporal and orbitofrontal regions with 7T fMRI.\n                  <\/jats:p>","DOI":"10.1002\/hbm.70621","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:44:33Z","timestamp":1786376673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimising\n                    <scp>7T<\/scp>\n                    \u2010\n                    <scp>fMRI<\/scp>\n                    for Imaging Regions of Magnetic Susceptibility"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-6900","authenticated-orcid":false,"given":"Saskia L.","family":"Frisby","sequence":"first","affiliation":[{"name":"MRC Cognition and Brain Sciences Unit University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-7040","authenticated-orcid":false,"given":"Marta M.","family":"Correia","sequence":"additional","affiliation":[{"name":"MRC Cognition and Brain Sciences Unit University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-6070","authenticated-orcid":false,"given":"Minghao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-1197","authenticated-orcid":false,"given":"Christopher T.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-755X","authenticated-orcid":false,"given":"Timothy T.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Institute of Cognitive Neuroscience University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5907-2488","authenticated-orcid":false,"given":"Matthew A.","family":"Lambon Ralph","sequence":"additional","affiliation":[{"name":"MRC Cognition and Brain Sciences Unit University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-7948","authenticated-orcid":false,"given":"Ajay D.","family":"Halai","sequence":"additional","affiliation":[{"name":"MRC Cognition and Brain Sciences Unit University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20321"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27620"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053\u20108119(03)00336\u20107"},{"key":"e_1_2_11_5_1","volume-title":"Advanced Normalization Tools (ANTS)","author":"Avants B. 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