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Here, we optimized CBV VASO on the NexGen 7T scanner for layer\u2010specific investigations of the human hippocampus. Both VASO and BOLD (from the same acquisition) detected significant hippocampal activation during an established autobiographical memory task. At the macroscale, activation patterns converged, showing pronounced memory task activation in the anterior hippocampus and consistent engagement across the frontoparietal neocortex. At the laminar scale, however, differences in depth\u2010dependent profiles emerged within the subiculum: BOLD exhibited a pronounced bias toward the inner layers, consistent with the known venous drainage pattern in the subfield. Finally, the optimized effective TR of 3.2\u2009s allowed exploratory study of retrieval stages and neocortical functional connectivity, which both supported hippocampal anterior\u2013posterior dissociation using either VASO or BOLD. Thus, hippocampal fMRI allows mapping layer function with high accuracy and can provide deeper insights into a number of neuropsychological phenomena and disorders.<\/jats:p>","DOI":"10.1002\/hbm.70660","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:50:02Z","timestamp":1791978602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Imaging of Hippocampal Layers Using\n                    <scp>VASO<\/scp>\n                    and\n                    <scp>BOLD<\/scp>\n                    on the Next Generation (\n                    <scp>NexGen<\/scp>\n                    )\n                    <scp>7T<\/scp>\n                    Scanner"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6396-1904","authenticated-orcid":false,"given":"Suvi","family":"H\u00e4kkinen","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Helen Wills Neuroscience Institute University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-9559","authenticated-orcid":false,"given":"Alexander","family":"Beckett","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Helen Wills Neuroscience Institute University of California, Berkeley  Berkeley California USA"},{"name":"Advanced MRI Technologies  Sebastopol California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Helen Wills Neuroscience Institute University of California, Berkeley  Berkeley California USA"},{"name":"Advanced MRI Technologies  Sebastopol California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-2202","authenticated-orcid":false,"given":"Laurentius","family":"Huber","sequence":"additional","affiliation":[{"name":"Martinos Center MGH, Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Feinberg","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Helen Wills Neuroscience Institute University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.10.016"},{"key":"e_1_2_10_4_1","article-title":"Laminar Profile of Hippocampal Subfields During Spatial Navigation","volume":"32","author":"Ahmadi K.","year":"2024","journal-title":"Proceedings of the International Society of Magnetic Resonance in Medicine"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1162\/IMAG.a.1197"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"Ahmadi K. 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