{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:17:33Z","timestamp":1759011453126,"version":"3.38.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Care Science"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Bordetella pertussis<\/jats:italic>, the causative agent of whooping cough, is a significant contributor to recurrent persistent cough across all age groups, including vaccinated individuals. This seroepidemiological study aims to address the gap in understanding pertussis incidence by investigating its occurrence in individuals with persistent cough and describing the characteristics of affected patients admitted to clinical centers in Jahrom, Southwest Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study enrolled 110 patients with a cough persisting for at least 2\u2009weeks, admitted to clinical centers in Jahrom, Iran. Blood samples were collected at baseline and on day 21 of follow\u2010up. Serum samples were analyzed for anti\u2010pertussis toxin immunoglobulin G (anti\u2010PT\u2010IgG) levels using an enzyme\u2010linked immunosorbent assay. Demographic factors, including age, gender, occupation, area of residence, and family size, were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 110 participants, 77 (70%) were female, and seven patients (6.4%) tested seropositive for anti\u2010PT\u2010IgG. No significant associations were observed between pertussis incidence and the analyzed variables, including age, gender, occupation, area of residence (urban vs. rural), and family size (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). These findings underscore the importance of enhancing vaccination coverage to reduce the prevalence of <jats:italic>B. pertussis<\/jats:italic> in the community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the occurrence of pertussis in individuals presenting solely with a persistent cough, absent of classic symptoms. The findings emphasize the need for healthcare providers to conduct detailed assessments and utilize rapid diagnostic methods for timely detection. This is particularly crucial in regions with high vaccination rates but limited awareness of pertussis recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hcs2.70000","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T14:10:14Z","timestamp":1739801414000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Seroepidemiological Assessment of <i>Bordetella pertussis<\/i> in Jahrom, Southern Iran: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"4","author":[{"given":"Rahim","family":"Raufi","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Internal Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Zareian\u2010Jahromi","sequence":"additional","affiliation":[{"name":"Schol of Medicine Jahrom University of Medical Sciences Jahrom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Zangeneh","sequence":"additional","affiliation":[{"name":"School of Medicine Fasa University of Medical Sciences Fasa Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalil","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Center AJA University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-495X","authenticated-orcid":false,"given":"Reza","family":"Shahriarirad","sequence":"additional","affiliation":[{"name":"Thoracic and Vascular Surgery Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818619-0.00076-9"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-024-00821-2"},{"volume-title":"Characteristics of Anti\u2010Pertussis Toxin Antibodies After Vaccination and Infection","year":"2024","author":"Knuutila A.","key":"e_1_2_13_4_1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw529"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2008.05.010"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-48"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555819453.ch17"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035874"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.10.136"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195979"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2208514"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1357-x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5578\/mb.27692"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp15X686917"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1120"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814003483"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.47176\/mjiri.34.22"},{"key":"e_1_2_13_19_1","first-page":"44","article-title":"Evaluation of IgG Serum Level and PCR of Respiratory Secretion for Bordetella pertussis Among Adult Suspected Patients With Whooping Cough More Than Two Weeks","volume":"44","author":"Mehrzad B.","year":"2014","journal-title":"European Respiratory Journal"},{"issue":"2","key":"e_1_2_13_20_1","first-page":"128","article-title":"Seroprevalence of Bordetella pertussis Antibody in Pregnant Women in Iran","volume":"14","author":"Hashemi S. 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