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By investigating genes such as\n                    <jats:italic>PRKN<\/jats:italic>\n                    ,\n                    <jats:italic>PINK1<\/jats:italic>\n                    , and\n                    <jats:italic>DJ\u20101<\/jats:italic>\n                    , which influence pathways primarily related to oxidative stress, mitophagy, cell cycle regulation, and inflammation, this review provides insight into how PD genes may contribute to CRC tumorigenesis through interactions with gut microbes such as\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    and\n                    <jats:italic>Clostridium butyricum<\/jats:italic>\n                    . This review highlights a mechanistic bridge between neurodegeneration and cancer centered on mitochondrial dysfunction, mitophagy, and inflammation. The convergence of molecular mechanisms and gut microbiota in PD and CRC highlights promising avenues for microbiome\u2010targeted interventions alongside genetic and molecular approaches to advance novel diagnostic and therapeutic strategies for these two diseases. Importantly, therapeutic strategies should be considered in a holistic manner, as interventions for one disease may influence the course of another, and probiotics represent a unique modality with the potential to confer preventive and therapeutic benefits across both conditions.\n                  <\/jats:p>","DOI":"10.1002\/hcs2.70087","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T05:30:43Z","timestamp":1784439043000},"page":"495-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights"],"prefix":"10.1002","volume":"5","author":[{"given":"Jiacheng","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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