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We present causal estimates that targeted interventions aimed at methamphetamine input markets (\u2018precursor control\u2019) can temporarily increase retail street prices, but methamphetamine consumption is weakly responsive to higher drug prices. After the supply interventions, purity\u2010adjusted prices increased then quickly returned to pre\u2010treatment levels within 6\u201312 months, demonstrating the short\u2010term effects of precursor control. The price elasticity of methamphetamine demand is \u22120.13 to \u22120.21 for self\u2010admitted drug treatment admissions and between \u22120.24 and \u22120.28 for hospital inpatient admissions. We find some evidence of a positive cross\u2010price effect for cocaine, but we do not find robust evidence that increases in methamphetamine prices increased heroin, alcohol, or marijuana drug use. This study can inform policy discussions regarding other synthesized drugs, including illicit use of pharmaceuticals. 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