{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:52:02Z","timestamp":1784019122298,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Economics"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This analysis presents the results of a systematic review for health state utilities in multiple myeloma, as well as analysis of over 9,000 observations taken from registry and trial data. The 27 values identified from 13 papers are then synthesised in a frequentist nonparametric bootstrap model and a Bayesian meta\u2010regression. Results were similar between the frequentist and Bayesian models with low utility on disease diagnosis (approximately 0.55), raising to approximately 0.65 on first line treatment and declining slightly with each subsequent line. Stem cell transplant was also found to be a significant predictor of health\u2010related quality of life in both individual patient data and meta\u2010regression, with an increased utility of approximately 0.06 across different models. The work presented demonstrates the feasibility of Bayesian methods for utility meta\u2010regression, whilst also presenting an internally consistent set of data from the analysis of registry data. To facilitate easy updating of the data and model, data extraction tables and model code are provided as <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#hec3871-supitem-0001\">Data S1<\/jats:ext-link>. The main limitations of the model relate to the low number of studies available, particularly in highly pretreated patients.<\/jats:p>","DOI":"10.1002\/hec.3871","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T06:14:41Z","timestamp":1550729681000},"page":"653-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Frequentist and <scp>B<\/scp>ayesian meta\u2010regression of health state utilities for multiple myeloma incorporating systematic review and analysis of individual patient data"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-326X","authenticated-orcid":false,"given":"Anthony J.","family":"Hatswell","sequence":"first","affiliation":[{"name":"Department of Statistical Science University College London  London UK"},{"name":"Delta Hat Limited University Nottingham University Hospital  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Burns","sequence":"additional","affiliation":[{"name":"BresMed University Nottingham University Hospital  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4314-2570","authenticated-orcid":false,"given":"Gianluca","family":"Baio","sequence":"additional","affiliation":[{"name":"Department of Statistical Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Wadelin","sequence":"additional","affiliation":[{"name":"Nottingham University Hospital  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1548-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.09.1232"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.03.1207"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.12.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"Canty A. &Ripley B.(2016).boot: Bootstrap R (S\u2010Plus) Functions. R Package Version 1.3\u201318.","DOI":"10.1002\/9781118445112.stat06177.pub2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0220-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511802843"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.19.1004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.120121"},{"key":"e_1_2_8_11_1","unstructured":"Dias S. Welton N. J. Sutton A. J. &Ades A. E.(2011).NICE DSU technical support document 1: Introduction to evidence synthesis for decision making.University of Sheffield Decision Support Unit 1\u201324."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf215"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X15575285"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7133.736"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00414-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00193.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.07.321"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.30_suppl.7"},{"key":"e_1_2_8_19_1","unstructured":"NICE. (2008).NICE guide to the methods of technology appraisal. Retrieved fromhttps:\/\/www.nice.org.uk\/process\/pmg9\/"},{"key":"e_1_2_8_20_1","unstructured":"NICE. (2009).Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy. Retrieved February 24 2017 fromhttps:\/\/www.nice.org.uk\/guidance\/ta171"},{"key":"e_1_2_8_21_1","unstructured":"NICE. (2013).Guide to the methods of technology appraisal. Retrieved June 8 2017 fromhttps:\/\/www.nice.org.uk\/process\/pmg9\/chapter\/the\u2010reference\u2010case"},{"key":"e_1_2_8_22_1","unstructured":"NICE. (2014).Bortezomib for induction therapy in multiple myeloma before high\u2010dose chemotherapy and autologous stem cell transplantation. Retrieved February 24 2017 fromhttps:\/\/www.nice.org.uk\/guidance\/ta311"},{"key":"e_1_2_8_23_1","unstructured":"NICE. (2017).Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib. Retrieved March 15 2017 fromhttps:\/\/www.nice.org.uk\/guidance\/ta427"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2013.28.3.263"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-015-0310-y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-70"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-12-35"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.09.1233"},{"key":"e_1_2_8_29_1","unstructured":"R Core Team. (2017).R: A language and environment for statistical computing. Vienna Austria: R Foundation for Statistical Computing. Retrieved fromhttps:\/\/www.R\u2010project.org\/"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-647636"},{"issue":"11","key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1182\/blood.V106.11.2547.2547","article-title":"Bortezomib continues demonstrates superior efficacy compared with high\u2010dose dexamethasone in relapsed multiple myeloma: Updated results of the APEX trail","volume":"106","author":"Richardson P.","year":"2005","journal-title":"Blood"},{"key":"e_1_2_8_32_1","unstructured":"Stan Development Team. (2016).RStan: The R interface to Stan. Retrieved fromhttp:\/\/mc\u2010stan.org\/"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X02238300"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200321030-00004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00346.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"}],"container-title":["Health Economics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhec.3871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hec.3871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hec.3871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hec.3871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:19:48Z","timestamp":1694344788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hec.3871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,20]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/hec.3871"],"URL":"https:\/\/doi.org\/10.1002\/hec.3871","archive":["Portico"],"relation":{},"ISSN":["1057-9230","1099-1050"],"issn-type":[{"value":"1057-9230","type":"print"},{"value":"1099-1050","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,20]]},"assertion":[{"value":"2018-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}