{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:52:35Z","timestamp":1761101555817},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,11,29]],"date-time":"2001-11-29T00:00:00Z","timestamp":1006992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Economics"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cystic fibrosis (CF) is the most common life\u2010shortening genetically transmitted disease in Denmark with a birth prevalence of 1 in 4700, resulting in 12\u201315 new cases of cystic fibroses annually.<\/jats:p><jats:p>The aim of this study is to disclose the societal resource implications of introducing a population wide prenatal screening programme for cystic fibrosis in Denmark. The present analysis is limited to the monetary consequences of introducing a screening programme, where costs of screening are compared to the potential benefits measured in cost savings involved if births of CF patients are avoided.<\/jats:p><jats:p>Screening costs in a Danish setting were estimated at DKK 2 771 262 (\u00a3231 438) per aborted affected fetus in the first screening round, stabilising at DKK 1 864 594 (\u00a3155 383) per aborted affected fetus at subsequent screening rounds. Comparing this figure with the estimated benefits of avoiding a CF case (DKK 2.1\u20134.4 million; \u00a3175 000\u2013366 667) suggests that introducing a screening programme for cystic fibrosis will be net cost saving irrespective of the perspective of the analysis, assumptions on replacement children and method of estimating long\u2010term production gains\/losses. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hec.652","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:27:00Z","timestamp":1030318020000},"page":"285-299","source":"Crossref","is-referenced-by-count":23,"title":["Prenatal screening for cystic fibrosis: an economic analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Randi","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte","family":"Gyrd\u2010Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11,29]]},"reference":[{"issue":"33","key":"e_1_2_1_2_2","article-title":"Anl\u0107gsb\u0107rerscreening for cystisk fibrose. Resultatet af en pilotunders\u00f8gelse blandt gravid","volume":"158","author":"Brandt NJ","year":"1996","journal-title":"Ugeskr L\u0153g"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09876.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4730030104"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90476-J"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/302042"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000472417","article-title":"Screening for carriers of cystic fibrosis among pregnant women: a pilot study","volume":"1","author":"Schwartz M","year":"1993","journal-title":"Eur J Genet"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-6296(96)00507-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(92)90131-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-6296(97)00006-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7018.1460"},{"key":"e_1_2_1_12_2","unstructured":"S\u00f8rensenLH.Det aldersfordelte forbrug af sundhedsydelser. CHS arbejdsnotat 1996:10. CHS Working paper Odense University. (in Danish)."},{"key":"e_1_2_1_13_2","unstructured":"Danmarks Statistik: Statistisk \u00c5rbog 1998. Danish Statistics. Yearbook1998."},{"key":"e_1_2_1_14_2","unstructured":"Bureau of Labour Statistics 1997: Consumer Expenditure Survey. Internet adress:http:\/\/stats.bls. gov\/csxstnd.htm#1997."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.32.4.282"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X9801800209"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4730040602"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199105000-00007"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/096914139500200107"},{"issue":"6","key":"e_1_2_1_20_2","first-page":"903","article-title":"The cost effectiveness of prenatal screening for cystic fibrosis","volume":"84","author":"Lieu TA","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.3.298"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jms.6.2.60"}],"container-title":["Health Economics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhec.652","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hec.652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T13:41:04Z","timestamp":1700314864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hec.652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,29]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/hec.652"],"URL":"https:\/\/doi.org\/10.1002\/hec.652","archive":["Portico"],"relation":{},"ISSN":["1057-9230","1099-1050"],"issn-type":[{"value":"1057-9230","type":"print"},{"value":"1099-1050","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11,29]]}}}