{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:07:07Z","timestamp":1762520827762,"version":"3.30.2"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T00:00:00Z","timestamp":1036368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Patients with tonsillar carcinoma and neck nodes seen at the clinic are not an uncommon occurrence in head and neck practice. Over the years, treatment has ranged from radical jaw neck dissection to radical neck dissection for the nodes and primary radiotherapy to the primary site. Much controversy exists as to which treatment modality yields the best survival. Certainly, surgery to the oropharynx leads to gross morbidity, with problems of swallowing, speech, and cosmesis, although it has been claimed that radiotherapy with neck dissection yields a lower cure rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We investigated a retrospective series of 96 patients all of whom had squamous cell carcinoma of the tonsil and associated lymph node metastases. Of these, 44 primary tumors were treated with surgery and 52 with irradiation. All 44 patients in the surgery group had a radical neck dissection, as did all but 12 in the radiotherapy group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of the tabulations, patients in good general condition were more likely to receive primary surgery. Overall cause\u2010specific survival for all patients was 69%. Multiple logistic regression revealed no associations; thus, the radiotherapy and surgery groups were well matched. Five\u2010year actuarial survival for those having irradiation was 74%. The five\u2010year survival for the group receiving surgery was 63% (<jats:italic>p<\/jats:italic>= .4372). This lack of difference between survival for surgery and radiotherapy was confirmed using Cox's proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>We conclude that tonsillar carcinoma with lymph nodes can be safely treated by applying appropriate radiotherapy to the tonsillar region and treating the neck with radical surgery, if the disease is more than N1. \u00a9 2002 Wiley Periodicals, Inc. Head Neck 24: 000\u2013000, 2002<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.10183","type":"journal-article","created":{"date-parts":[[2002,12,12]],"date-time":"2002-12-12T14:08:57Z","timestamp":1039702137000},"page":"24-31","source":"Crossref","is-referenced-by-count":11,"title":["The treatment of squamous cell carcinoma of the tonsil with neck node metastases"],"prefix":"10.1002","volume":"25","author":[{"given":"Andrew Simpson","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Eugene","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David John","family":"Husband","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,4]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"11","article-title":"Tonsil cancer","volume":"141","author":"Bopp FP","year":"1989","journal-title":"J Louisiana St Med Soc"},{"key":"e_1_2_5_3_2","first-page":"373","volume-title":"Stell and Maran's head and neck surgery","author":"Stell PM","year":"1978"},{"volume-title":"UICC TNM classification in malignant tumours","year":"1997","author":"Hermanek P","key":"e_1_2_5_4_2"},{"key":"e_1_2_5_5_2","first-page":"9","volume-title":"Manual for staging of cancer","author":"Beahrs OH","year":"1988"},{"volume-title":"Users guide: statistics version","year":"1985","author":"SAS Institute Inc","key":"e_1_2_5_6_2"},{"key":"e_1_2_5_7_2","first-page":"436","volume-title":"Statistical methods in medical research","author":"Armitage P","year":"1987"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_2_5_9_2","first-page":"54","volume-title":"Statistics with confidence","author":"Gardner NJ","year":"1989"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables [with discussion]","volume":"34","author":"Cox DR","year":"1972","journal-title":"J Roy Stat Soc"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185386"},{"key":"e_1_2_5_12_2","first-page":"296","article-title":"Carcinoma of the tonsil: prognostic factors","volume":"26","author":"Abdulwahed S","year":"1997","journal-title":"J Otolaryngol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1996.tb01110.x"},{"key":"e_1_2_5_14_2","first-page":"263","article-title":"Tonsillar carcinoma: analysis of treatment results","volume":"27","author":"Wang MB","year":"1998","journal-title":"J Otolaryngol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00291-0"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00228-Q"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00119-9"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.10183","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.10183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T14:54:22Z","timestamp":1733928862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.10183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,4]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/hed.10183"],"URL":"https:\/\/doi.org\/10.1002\/hed.10183","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[2002,11,4]]}}}