{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:31:25Z","timestamp":1770712285508,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T00:00:00Z","timestamp":1036368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aims.<\/jats:title><jats:p>It has been speculated that impaired salivary flow contributes to autoimmune thyroiditis (chronic thyroiditis, Hashimoto's thyroiditis). To test this hypothesis, salivary function was measured by quantitative salivary scintigraphy in autoimmune thyroiditis patients, as well as in age\u2010 and gender\u2010matched controls for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology.<\/jats:title><jats:p>One hundred and twenty patients with an autoimmune thyroiditis history of more than 10 years each and 36 healthy controls were enrolled in the study. All the 120 autoimmune thyroiditis patients had good blood sugar control. None had autonomic neuropathy. These 120 autoimmune thyroiditis patients were separated into two subgroups: group 1, 60 patients with xerostomia; and group 2, 60 patients without xerostomia. After intravenous injection of 5 mCi Tc\u201099m pertechnetate, sequential images at 1 min\/frame were acquired for 30 min. The first\u2010 and 15th\u2010minute uptake ratios (UR) were calculated from the tracer uptakes in the four major salivary glands over the background regions of interest (ROIs). Saliva excretion was stimulated by 1 tablet of 200 mg ascorbic acid given orally 15 min after injection of the tracer. Then, the maximal excretion ratios (ER) of the four major salivary glands after sialagogue stimulation were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Impaired salivary function, represented by significantly decreased UR and ER values, in autoimmune thyroiditis patients with xerostomia was demonstrated in this study. In addition, there was a significantly higher prevalence of salivary gland dysfunction in group 1 patients than in group 2 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Significantly poorer salivary function was found in autoimmune thyroiditis patients with xerostomia compared with autoimmune thyroiditis patients without xerostomia and healthy controls by means of objective and quantitative salivary scintigraphy. \u00a9 2003 Wiley Periodicals, Inc. Head Neck 25: 132\u2013137, 2003<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.10192","type":"journal-article","created":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T21:01:32Z","timestamp":1041454892000},"page":"132-137","source":"Crossref","is-referenced-by-count":17,"title":["Decreased salivary gland function in patients with autoimmune thyroiditis"],"prefix":"10.1002","volume":"25","author":[{"given":"Cheng\u2010Pei","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chien","family":"Shiau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhi\u2010Joung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shung\u2010Tai","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hung","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(93)90025-T"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.1996.tb00844.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270205"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1988.tb19634.x"},{"key":"e_1_2_6_6_2","first-page":"95","article-title":"Periductal lymphocytic infiltrates in salivary glands in myasthenia gravis patients lacking Sj\u00f6gren's syndrome","volume":"66","author":"Lindahl G","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_7_2","first-page":"267","article-title":"Lymphocytic infiltration and HLA\u2010DR expression of salivary glands in bone marrow transplant recipients: a prospective study","volume":"72","author":"Lindahl G","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748809105274"},{"key":"e_1_2_6_9_2","first-page":"163","article-title":"Studies on the specificity of the immunohistopathological changes of the salivary glands in Sj\u00f6gren's syndrome","volume":"7","author":"Hedfors E","year":"1989","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-198901030-00015"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.4.286"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350206"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90061-T"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231118"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197704212961602"},{"key":"e_1_2_6_16_2","first-page":"147","volume-title":"Autoimmune diseases: focus on Sj\u00f6gren's syndrome","author":"Arnett FC","year":"1994"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1001\/jama.1971.03180390021005","article-title":"Xerostomia in Sj\u00f6gren's syndrome. Evaluation by sequential salivary scintigraphy","volume":"216","author":"Schall GL","year":"1971","journal-title":"JAMA"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780220801"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940615)73:12<2886::AID-CNCR2820731203>3.0.CO;2-K"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.12.1463"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007658"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.19810"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8177(87)54012-0"},{"issue":"5","key":"e_1_2_6_24_2","first-page":"7","article-title":"Xerostomia","volume":"8","author":"Manthorpe R","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_25_2","unstructured":"KohnWG ShipJA AtkinsonJC PattonLL FoxPC.Salivary gland 99mTc\u2010scintigraphy: a grading scale and correlation with major salivary gland flow rates."},{"key":"e_1_2_6_26_2","first-page":"2378","article-title":"Scintigraphic description of salivary glands of the head with technetium\u201099m","volume":"42","author":"Borner W","year":"1965","journal-title":"Med Welt"},{"key":"e_1_2_6_27_2","first-page":"431","article-title":"The effect of cigarette smoking on salivation and esophageal acid clearance","volume":"114","author":"Kahrilas PJ","year":"1989","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_28_2","first-page":"416","article-title":"Changes of the neurovegetative reactivity under the influence of large amounts of vitamin C","volume":"32","author":"Zdichynec B","year":"1978","journal-title":"Cesk Gastroenterol Vyz"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.10192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:06:27Z","timestamp":1700244387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.10192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,4]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1002\/hed.10192"],"URL":"https:\/\/doi.org\/10.1002\/hed.10192","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,4]]}}}