{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:12:10Z","timestamp":1792059130549,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,1,17]],"date-time":"2003-01-17T00:00:00Z","timestamp":1042761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction.<\/jats:title><jats:p>Few studies have examined prognostic factors that have an impact on outcomes in anterior skull base surgery by multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We retrospectively examined our institution's skull base experience from 1973\u20132000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>During this time, 166 patients underwent an anterior skull base resection for malignancy (median age, 53 years; range, 6\u201392 years). The 5\u2010year relapse\u2010free and disease\u2010specific survival was 41% and 57% (median follow\u2010up, 53 months). Multivariate analysis found that dural invasion, primary histologic diagnosis, and margin status had a significant impact on relapse\u2010free and disease\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>These data indicate that patients with anterior skull base malignancies are treated successfully with skull base surgery. Patients demonstrating adverse prognostic variables such as dural invasion, adverse histologic findings, and\/or positive margins should be considered for the addition of adjuvant therapy or innovative therapies as they become available in the future. \u00a9 2003 Wiley Periodicals, Inc. 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