{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:13:41Z","timestamp":1787163221229,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,1,24]],"date-time":"2003-01-24T00:00:00Z","timestamp":1043366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Gustatory sweating is a common complication of parotid surgery. Injection of botulinum toxin A has been reported as a safe and effective treatment option for patients with Frey's syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods.<\/jats:title>\n                    <jats:p>\n                      A total of 69 patients who had undergone superficial parotidectomy because of adenoma were evaluated with respect to the incidence of Frey's syndrome and treatment interest. Minor's iodine starch test was used to detect the affected skin area. Affected skin areas were documented using a digital camera; skin areas were evaluated morphometrically. A single injection of Botox per 1 cm\n                      <jats:sup>2<\/jats:sup>\n                      skin field was administered to those patients interested in treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Of 43 patients (62%) with gustatory sweating, 33 patients requested treatment. The affected skin area varied from 16 cm\n                      <jats:sup>2<\/jats:sup>\n                      to 81 cm\n                      <jats:sup>2<\/jats:sup>\n                      . The individual Botox dosage ranged from 16 to 80 IU. All relevant clinical symptoms of sweating disappeared within 1 week after a single injection. Treatment was well tolerated with no side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Botox A injection is a safe and effective treatment with long\u2010lasting effects for patients with extensive gustatory sweating. \u00a9 2003 Wiley Periodicals, Inc. Head Neck 25: 624\u2013628, 2003<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.10262","type":"journal-article","created":{"date-parts":[[2003,7,23]],"date-time":"2003-07-23T06:12:39Z","timestamp":1058940759000},"page":"624-628","source":"Crossref","is-referenced-by-count":61,"title":["Treatment of gustatory sweating (Frey's syndrome) with botulinum toxin A"],"prefix":"10.1002","volume":"25","author":[{"given":"Andr\u00e9","family":"Eckardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kuettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,21]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"431","article-title":"Observations sur les Fistules du Canal Salivaire de Stenon. Sur une plague compliqu\u00e9e a la ione ou le canal fut d\u00e9chin\u00e9","volume":"3","author":"Duphenix M","year":"1757","journal-title":"Mem Acad R Chir"},{"key":"e_1_2_5_3_2","first-page":"97","article-title":"Le syndrome du nerf auriculo\u2010temporal","volume":"2","author":"Frey L","year":"1923","journal-title":"Rev Neurol Paris"},{"key":"e_1_2_5_4_2","first-page":"53","article-title":"Pr\u00e4valenz des Frey\u2010Syndroms nach Parotidektomie","volume":"56","author":"K\u00fcttner C","year":"2001","journal-title":"DZZ"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016485709124377"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509139348"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01652699"},{"key":"e_1_2_5_8_2","first-page":"137","article-title":"Severe Frey syndrome after parotidectomy: treatment with botulinum neurotoxin type A","volume":"6","author":"Laccourreye O","year":"1999","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199711000-00013"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487409124638"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(78)90020-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80343-5"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1288\/00005537-198010000-00008","article-title":"Frey's syndrome: incidence related to skin flap thickness in parotidectomy","volume":"90","author":"Sengleton G","year":"1980","journal-title":"Laryngoscope"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459980112400617"},{"key":"e_1_2_5_15_2","first-page":"29","article-title":"Gustatory local hyperhidrosis following injuries in the parotid region","volume":"93","author":"Langenskj\u00f6ld A","year":"1946","journal-title":"Acta Chir Scand"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200606"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110115"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199006000-00019"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997246"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/71.1.16"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1967.00760050004002"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1956.02960390022007"},{"key":"e_1_2_5_23_2","first-page":"11","article-title":"The action of botulinumtoxin at the neuromuscular junction","volume":"59","author":"Sellin L","year":"1981","journal-title":"Med Biol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420619"},{"key":"e_1_2_5_25_2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1017\/S0022215100138769","article-title":"Frey's syndrome: treatment with botulinum toxin","volume":"11","author":"Bjerkhoe A","year":"1997","journal-title":"J Laryngol Otol"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199803000-00013"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70008-8"},{"issue":"1","key":"e_1_2_5_28_2","first-page":"90","article-title":"Treatment of Frey's syndrome with botulinum toxin A: Which is the ideal dose?","volume":"30","author":"Nolte D","year":"2002","journal-title":"J Craniomaxillofac Surg"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007817"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.10262","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.10262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T07:08:58Z","timestamp":1700204938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.10262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,21]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1002\/hed.10262"],"URL":"https:\/\/doi.org\/10.1002\/hed.10262","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,21]]}}}