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Patient data and tumor and treatment factors were recorded. Comorbidity was graded by an Adult Comorbidity Evaluation 27 (ACE\u201027) test. Postoperative complications were scored according to their severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Comorbidity score ACE\u201027 grade 2 or higher was present in 47% of patients, whereas 33% had a clinically important complication develop. A comorbidity score of ACE\u201027 grade \u22652 was a strong predictor for complications (<jats:italic>p <\/jats:italic>&lt; .001). There were no other predictors for postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Comorbidity is of great importance for prediction of postoperative complications in head and neck cancer patients, especially an ACE\u201027 grade \u22652. It may be concluded from these results that prevention of complications should focus on comorbidities. \u00a9 2003 Wiley Periodicals, Inc. 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