{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:39:09Z","timestamp":1783967949469,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,3,30]],"date-time":"2001-03-30T00:00:00Z","timestamp":985910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical management of recurrent pleomorphic adenoma of the parotid gland has a considerable risk of facial nerve injury and a high re\u2010recurrence rate. To obtain more insight into this issue we evaluated our experiences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records and histologic material of all these patients (31 women and 21 men), who had been treated from 1976\u20131995 were reviewed. Median interval between initial treatment and commencement of recurrences was 3 (0.8\u201318) years. Last surgery consisted of parotidectomy in 48 patients (92%), including 19 (40%) total procedures and wide local excision with involved skin in four patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median follow\u2010up of 9 years, eight patients (8\/52; 15%) had re\u2010recurrences develop, including 4 of 21 patients (19%) after a previous parotidectomy (group I) and 4 of 31 patients (13%) without prior parotidectomy (group II). The chance of re\u2010recurrence in a group of patients with a minimal follow\u2010up of 10 years after salvage surgery was 17% (4 of 24). The risk of a new relapse was, respectively, 4% and 8% at 1 and 5 years after treatment of recurrent disease. Acceptable N.VII function was preserved in 45 of the 49 (92%) nerves at risk. The risk of N.VII injuy was higher and more serious in group I (29% vs 10% in group II). The function of four of the five (80%) reconstructed zygomaticotemporal branches of the N.VII was adequate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgical treatment of recurrent pleomorphic adenoma of the parotid gland, usually consisting of a parotidectomy with wide extent and eventually facial nerve reconstruction, demonstrates favorable results with acceptable morbidity. The risk of new relapse and N.VII injury was higher after previous parotidectomy. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 311\u2013316, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1036","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:37:10Z","timestamp":1030307830000},"page":"311-316","source":"Crossref","is-referenced-by-count":59,"title":["Surgical treatment of recurrent pleomorphic adenoma of the parotid gland: A clinical analysis of 52 patients"],"prefix":"10.1002","volume":"23","author":[{"given":"Afina S.","family":"Glas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Vermey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Hollema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.N.","family":"Roodenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul E.","family":"Nap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Th. M.","family":"Plukker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,3,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198403000-00006"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1997.02551.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800290031007"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400203"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90321-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880170302"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016486809126313"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100123667"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780110056007"},{"key":"e_1_2_1_11_2","first-page":"28","article-title":"Pleomorphe Pa\u2010rotisadenome und ihre Rezidive","volume":"42","author":"Federspil PA","year":"1994","journal-title":"HNO"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790170017004"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90318-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780060061006"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90501-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-83501-8_13"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90789-K"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_1_19_2","unstructured":"MolenaarBB.Speekselkliergezwellen. Thesis. Groningen 1958."},{"key":"e_1_2_1_20_2","unstructured":"VermeyA.Benign epithelial parotid tumors. Thesis. Groningen 1989."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980215)82:4<617::AID-CNCR1>3.0.CO;2-I"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004519314"},{"key":"e_1_2_1_23_2","first-page":"426","article-title":"Zur Chirurgie des pleomorphen Adenomas der Ohrspeicheldruse","volume":"37","author":"Glass von W","year":"1989","journal-title":"HNO"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880120410"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790170017004"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800730130"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00293-0"},{"key":"e_1_2_1_28_2","unstructured":"FrelingNJM.MRI van parotistumoren. Thesis. Groningen 1991."},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198005000-00022"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198901000-00007"},{"key":"e_1_2_1_31_2","first-page":"1","volume-title":"Tumors of the head and neck: clinical and pathological considerations","author":"Batsakis JG","year":"1979"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4962.322"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179377"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800730803"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-65-777-833"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.1036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.1036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T12:25:34Z","timestamp":1700310334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.1036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,30]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1002\/hed.1036"],"URL":"https:\/\/doi.org\/10.1002\/hed.1036","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,30]]}}}