{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:27:46Z","timestamp":1761647266567},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,1,5]],"date-time":"2004-01-05T00:00:00Z","timestamp":1073260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Postoperative radiotherapy is necessary for squamous cell carcinoma (SCC) of the oral cavity with positive or close margins. The aim of the study is to define the indications of postoperative brachytherapy (BRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>From 1979 to 1993, 82 patients with positive or close margins had postoperative BRT (58 T1\u20132, 24 T3\u20134, 45 mobile tongue, 37 floor of mouth). Forty\u2010six patients had combined radiotherapy (RT) with a mean dose of 48 Gy, and BRT boost with a mean dose of 24 Gy. Thirty\u2010six patients had BRT alone with a mean dose of 60 Gy. BRT was performed with interstitial low dose rate Iridium 192.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Overall survival (OS), cause\u2010specific survival (CSS), and local control (LC) at 5 years were, respectively, for T1\u20132\/N0N\u2212 with BRT, 75%, 85%, and 88%,and with RT\u2010BRT 70%, 92%, and 92%; for T1\u20132\/N+ with RT\u2010BRT, 44%, 67%, and 78%; for T3\u20134\/N\u2212 with RT\u2010BRT, 42%, 90%, and 80%; and for T3\u20134\/N+ with RT\u2010BRT, 22%, 43%, and 57%. Prognostic factors for OS, CSS, and LC were N+ (<jats:italic>p<\/jats:italic> \u2264 .009), extracapsular spread (ECS+;<jats:italic>p<\/jats:italic> \u2264 .000001), and T stage for LC only (<jats:italic>p<\/jats:italic> = .02). Prognostic factors for complications were a high number of wires with a cutoff at five wires (<jats:italic>p<\/jats:italic> = .008), a high dose rate with a cutoff at 0.57 Gy\/hr (<jats:italic>p<\/jats:italic> = .01), and a high total dose (BRT + RT) with a cutoff at 71 Gy (<jats:italic>p<\/jats:italic> = .07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>BRT alone for SCC T1\u20132\/N0N\u2212 is better than RT\u2010BRT because, with equivalent results, it avoids the adverse events of postoperative RT (xerostomia) and permits the treatment of a second head and neck primary in nonirradiated tissue. The results for the T3\u20134\/N\u2212 are acceptable with this approach (ie, RT\u2010BRT) but may be improved for N+. \u00a9 2004 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>26:<\/jats:bold> 216\u2013223, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.10377","type":"journal-article","created":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T08:01:02Z","timestamp":1078128062000},"page":"216-223","source":"Crossref","is-referenced-by-count":43,"title":["Postoperative brachytherapy alone and combined postoperative radiotherapy and brachytherapy boost for squamous cell carcinoma of the oral cavity, with positive or close margins"],"prefix":"10.1002","volume":"26","author":[{"given":"Michel","family":"Lapeyre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc 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