{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:59:36Z","timestamp":1788328776923,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T00:00:00Z","timestamp":1077580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Desmoplastic variants of melanoma rarely affect the mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method.<\/jats:title><jats:p>The clinicopathologic features and p53 status of seven primary mucosal desmoplastic melanomas of the oral and nasal cavity were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The patients included six men and one woman (median age, 61 years; range, 23\u201374 years). Desmoplastic melanoma involved the lip in two, alveolus in three, buccal mucosa in one, and nasal vestibule in one patient. Four tumors infiltrated up to lamina propria, and three infiltrated bone and\/or cartilage. All were amelanotic spindle cell tumors, five were neurotropic, and two were vasoinvasive. Aberrant p53 expression was seen in six tumors. All tumors recurred locally, and distant metastasis developed in three. Six patients died with disease (survival, 1\u201341 years; median, 8 years), and one patient was free of disease (survival 20 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Primary mucosal desmoplastic melanomas are clinically characterized by local recurrence and may lead to distant metastasis and death even after several years. Alterations in p53 expression are frequently associated with desmoplastic melanoma. \u00a9 2003 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>26:<\/jats:bold> 373\u2013377, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.10384","type":"journal-article","created":{"date-parts":[[2004,3,24]],"date-time":"2004-03-24T14:01:53Z","timestamp":1080136913000},"page":"373-377","source":"Crossref","is-referenced-by-count":53,"title":["Primary mucosal desmoplastic melanoma of the head and neck"],"prefix":"10.1002","volume":"26","author":[{"given":"Manju L.","family":"Prasad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus J","family":"Busam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1971)28:4<914::AID-CNCR2820280415>3.0.CO;2-E"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950115)75:2<478::AID-CNCR2820750211>3.0.CO;2-O"},{"key":"e_1_2_6_4_2","first-page":"703","article-title":"Unusual variants of melanoma: fact or fiction?","volume":"23","author":"Sagebiel RW","year":"1996","journal-title":"Semin Oncol"},{"key":"e_1_2_6_5_2","first-page":"107","article-title":"Desmoplastic melanoma of the maxillary alveolus","volume":"37","author":"Batsakis JG","year":"1979","journal-title":"J Oral Surg"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198905000-00003"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(92)90026-T"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90383-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80250-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960801)78:3<383::AID-CNCR1>3.0.CO;2-L"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1300"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-579X(02)00134-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00010"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200207000-00006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10019"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02071519"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200209000-00007"},{"key":"e_1_2_6_18_2","first-page":"223A","article-title":"Expression and prognostic significance of cell cycle and apoptosis related proteins p53, p16 INK4A and bcl\u20102 in primary mucosal melanomas of the head and neck","volume":"15","author":"Prasad ML","year":"2002","journal-title":"Mod Pathol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502163320704"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910640109"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.10384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.10384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T03:46:10Z","timestamp":1700192770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.10384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,24]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1002\/hed.10384"],"URL":"https:\/\/doi.org\/10.1002\/hed.10384","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,24]]}}}