{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:59:04Z","timestamp":1761893944491},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,3,10]],"date-time":"2004-03-10T00:00:00Z","timestamp":1078876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>The aim of the study was to evaluate the effectiveness of endoscopic CO<jats:sub>2<\/jats:sub> laser microsurgery in the management of supraglottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>One hundred twenty\u2010four patients (116 men and eight women; mean age, 59 years; range 31\u201381 years) with supraglottic cancer underwent CO<jats:sub>2<\/jats:sub> laser surgery (mean follow\u2010up 5 years). The study patients were classified as follows: 45 patients, T1N0M0; 61 patients, T2N0M0; and 18 patients, T3N0M0. According to the staging, the following procedures were adopted: epiglottectomy, resection of aryepiglottic fold or false vocal cord in T1 patients (group A); resection of the false vocal cord and adjacent structures in T2 patients (group B); and supraglottic laryngectomy in T3 patients (group C). Statistical comparison of survival parameters was carried out with Wilcoxon test, considering <jats:italic>p<\/jats:italic> &lt; .05 the minimum significance value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Overall actuarial survival, adjusted actuarial survival, and no evidence of disease at 5 years were 91%, 97%, and 82% in group A; 88%, 94%, and 59% in group B; and 81%, 81%, and 51% in group C, respectively. The statistical analysis of survival parameters showed a significant difference in the comparison of T1 versus T2 and T2 versus T3 tumors (<jats:italic>p<\/jats:italic> &lt; .01). Actuarial local control, actuarial nodal control, and actuarial distant metastasis control at 5 years were 82%, 82%, and 100% in T1 patients; 63%, 90%, and 98% in T2 patients; and 77%, 75%, and 93% in T3 patients. Laryngeal preservation rate was 88.6% in T1 patients, 85.4% in T2 patients, and 93.7% in T3 patients. Patients in groups A and B were discharged after 3 to 12 days, and patients in group C, were discharged after 14 to 20 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>The results of this study show that endoscopic CO<jats:sub>2<\/jats:sub> laser surgery is highly effective in the treatment of T1 and T2 supraglottic cancer. In T3 cancer, the CO<jats:sub>2<\/jats:sub> laser should be implemented in those cases where radical excision by endoscopic route is feasible. \u00a9 2004 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>26:<\/jats:bold> 442\u2013446, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.10395","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T21:02:15Z","timestamp":1081285335000},"page":"442-446","source":"Crossref","is-referenced-by-count":56,"title":["CO<sub>2<\/sub> laser treatment of supraglottic cancer"],"prefix":"10.1002","volume":"26","author":[{"given":"Gaetano","family":"Motta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Testa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Iovine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.9.1399"},{"key":"e_1_2_5_3_2","first-page":"49","article-title":"Il laser a CO2 nella microchirurgia laringea","volume":"4","author":"Motta G","year":"1984","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_5_4_2","first-page":"175","article-title":"CO2 Laser in laryngeal microsurgery","volume":"72","author":"Motta G","year":"1987","journal-title":"Int Surg"},{"key":"e_1_2_5_5_2","first-page":"135","article-title":"Experience in endoscopic laser surgery of malignant tumours of the upper aerodigestive tract","volume":"39","author":"Steiner W","year":"1988","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300301"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1998)23:2<79::AID-LSM5>3.0.CO;2-S"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800901"},{"key":"e_1_2_5_9_2","volume-title":"TNM classification of malignant tumors","author":"UICC","year":"1997"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.11.1245"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700810"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.112202"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050247"},{"key":"e_1_2_5_14_2","first-page":"269","article-title":"Laryngectomia supraglotica: resultados \u00e1 tres y \u00e1 5 a\u00f1os","volume":"50","author":"Herranz Gonzales J","year":"1999","journal-title":"Acta Otorrinolaringol Esp"},{"key":"e_1_2_5_15_2","first-page":"147","article-title":"R\u00e9sultats du traitement chirurgical des cancers de l'\u00e9tage sus\u2010glottique","volume":"110","author":"Chevalier D","year":"1993","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1017\/S0022215100138472","article-title":"Supraglottic laryngectomy\u2014series report and analysis of results","volume":"111","author":"Adamapoulos G","year":"1997","journal-title":"J Laryngol Otol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750045938"},{"key":"e_1_2_5_18_2","first-page":"215","volume-title":"Complications in head and neck surgery","author":"Krespi YP","year":"1993"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100608"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160305"}],"container-title":["Head &amp; 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