{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:40:22Z","timestamp":1785213622175,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,4,3]],"date-time":"2001-04-03T00:00:00Z","timestamp":986256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Juvenile xanthogranulomatosis (JXG) is a relatively rare macrophage proliferative disorder. It usually presents as a localized cutaneous lesion but may affect other organs. Until now it has never been described in the subglottic region of the larynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report the first case of juvenile xanthogranulomatosis (JXG) in the subglottis in a 3 year old child.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The localization in the subglottis caused airway obstruction requiring tracheostomy to secure the airway. On the basis that most cutaneous lesions regress spontaneously the lesion was managed expectantly and regressed over a period of 28 months allowing decannulation of the child.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>JXG should be considered in the differential diagnosis of subglottic lesions. Once the airway has been secured, JXG of the subglottis can be managed conservatively. Long\u2010term follow\u2010up is required because of the possibility of relapse at other sites. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 426\u2013429, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1053","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:28:49Z","timestamp":1030310929000},"page":"426-429","source":"Crossref","is-referenced-by-count":13,"title":["Isolated juvenile xanthogranuloma of the subglottis: Case report"],"prefix":"10.1002","volume":"23","author":[{"given":"Mahilravi S.","family":"Thevasagayam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Panarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Bull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,4,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199402000-00002"},{"key":"e_1_2_1_3_2","first-page":"455","article-title":"Epibulbar nevoxanthoendothelioma","volume":"53","author":"Cogan DG","year":"1962","journal-title":"Arch Opthalmol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1542\/peds.33.2.233","article-title":"Juvenile xanthogranuloma with pulmonary lesions: A case report","volume":"33","author":"Lottsfeldt F","year":"1964","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600190077017"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851101)56:9<2280::AID-CNCR2820560923>3.0.CO;2-L"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/archderm.1983.01650310015003","article-title":"Cutaneous histiocytosis X","volume":"119","author":"Rowden G","year":"1983","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_8_2","first-page":"209","article-title":"Histiocytosis syndromes in children","volume":"1","author":"Chu T","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80207-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)01107-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/archderm.1984.01650390093020","article-title":"Association of juvenile xanthogranuloma with juvenile myeloid leukaemia","volume":"120","author":"Cooper PH","year":"1984","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_12_2","first-page":"371","article-title":"Xantholeucema associ\u00e9e \u00e0 une neurofibromatose de von Recklinghausen","volume":"112","author":"Laroche L","year":"1985","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90226-9"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.1053","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.1053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T15:04:02Z","timestamp":1700406242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.1053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,3]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1002\/hed.1053"],"URL":"https:\/\/doi.org\/10.1002\/hed.1053","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,3]]}}}