{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:23:59Z","timestamp":1770719039346,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,7,2]],"date-time":"2001-07-02T00:00:00Z","timestamp":994032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphomas of T\u2010cell and T\/natural killer (T\/NK)\u2010cell types rarely involve the larynx. Early symptoms are subtle and nonspecific, and confirmation of the diagnosis is often difficult. Because of the rarity of this disease entity, the optimal management remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The case records of patients with the diagnosis of lymphoma involving the larynx were retrospectively reviewed. Details of the pathologic condition, the difficulties in diagnosis, and treatment were presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One case of T\u2010cell lymphoma (Lennert's lymphoma subtype) and two cases of T\/NK\u2010cell lymphomas involving the larynx were presented. The diagnoses were all difficult to establish. All three patients received either multiagent chemotherapy or radiotherapy as the first\u2010line treatment. They all died of the disease within 32 months of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>T\u2010 and T\/NK\u2010cell non\u2010Hodgkin's lymphoma of the larynx is a diagnostic challenge for clinicians and pathologists. Conventional chemotherapy or radiotherapy has not been effective. A more aggressive therapy should be considered. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 625\u2013628, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1088","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:59:21Z","timestamp":1030312761000},"page":"625-628","source":"Crossref","is-referenced-by-count":27,"title":["Unusual T\u2010 and T\/NK\u2010 cell non\u2010Hodgkin's lymphoma of the larynx: A diagnostic challenge for clinicians and pathologists"],"prefix":"10.1002","volume":"23","author":[{"given":"Johnny S. W.","family":"Mok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Wai","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. F.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A. van","family":"Hasselt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"327","volume-title":"Neoplasms of the larynx","author":"Ferlito A","year":"1993"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199711000-00014"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890901)64:5<1123::AID-CNCR2820640526>3.0.CO;2-Z"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840601)53:11<2546::AID-CNCR2820531128>3.0.CO;2-Y"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340202"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0889-8588(18)30396-4","article-title":"Non\u2010Hodgkin's lymphomas in Asia","volume":"5","author":"Shih LY","year":"1991","journal-title":"Hemat Oncol Clin North Am"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100137946"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198805000-00002"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1182\/blood.V89.12.4501","article-title":"Non\u2010nasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm","volume":"89","author":"Chan JKC","year":"1997","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199601000-00012"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01642550"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1069(199705)15:2<71::AID-HON601>3.0.CO;2-U"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.1462962.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70469-X"},{"key":"e_1_2_1_17_2","first-page":"29","article-title":"Radiation therapy for primary non\u2010Hodgkin lymphoma of the head and neck","volume":"9","author":"Teshima T","year":"1991","journal-title":"Radiat Med"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.1088","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.1088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:10:14Z","timestamp":1700413814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.1088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,2]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1002\/hed.1088"],"URL":"https:\/\/doi.org\/10.1002\/hed.1088","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,2]]}}}