{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:03:45Z","timestamp":1760897025397},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,7,2]],"date-time":"2001-07-02T00:00:00Z","timestamp":994032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study is to make a comparative analysis between acute toxicity with late toxicity. This study is based upon a French quality of life (QoL) questionnaire in a cohort of advanced head and neck (H&amp;N) cancer patients treated by concomitant twice\u2010a\u2010day continuous radiotherapy with no acceleration and chemotherapy with cisplatin and 5\u2010fluorouracil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From September 1992 to November 1997, a prospective data bank of 91 patients was constituted. In November 1999, 31 patients were still alive and followed for more than 3 years. All patients had stage IV strictly unresectable squamous cell carcinoma of oropharynx or hypopharynx. A French specific H&amp;N cancer QoL questionnaire was used at the end of radiotherapy and at the last date of follow\u2010up of each patient (during 1999). <jats:italic>p<\/jats:italic> values reflect comparison of percentages obtained at the end of treatment with percentages at long\u2010term follow\u2010up. Statistical analysis was performed using \u03c7<jats:sup>2<\/jats:sup> test (<jats:italic>p<\/jats:italic> &lt; .05 considered as significant). Percentages obtained by the QoL questionnaire correspond to moderate\u2010severe problems only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine of 31 (94%) patients participated in the QoL study. Acute treatment toxicities were severe with declines in virtually all QoL and functional domains. Globally, with an average long\u2010term follow\u2010up of 4.5 years (range 3\u20137 years after treatment), there is a statistical improvement in the following symptoms: dry mouth and sticky saliva (97% versus 55%, <jats:italic>p<\/jats:italic> &lt; .05); tasting problems (35% versus 21%, not significant); swallowing problems (77% versus 36%, <jats:italic>p<\/jats:italic> &lt; .05); and H&amp;N pain (86% versus 9%, <jats:italic>p<\/jats:italic> &lt; .05). Financial problems were not improved (21% versus 14%, not significant), and psychological problems (59% versus 5%) were statistically significant. Fourteen of 29 (48%) patients were drinking and 8 of 29 (28%) were smoking at long\u2010term follow\u2010up; at the diagnosis they were 86% and 90%, respectively. At long\u2010term follow\u2010up 22 of 29 presented good or very good QoL, and 25 of 29 said they had improved their initial QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The interest of twice\u2010a\u2010day radiotherapy with concomitant chemotherapy is to increase total radiotherapy equivalent dose without increasing late toxicity and also to improve locoregional control, survival, and long\u2010term QoL\/effectiveness ratio. Best supportive care is recommended to obtain both good QoL and cancer control in a long\u2010term follow\u2010up. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 678\u2013682, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1095","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:59:21Z","timestamp":1030312761000},"page":"678-682","source":"Crossref","is-referenced-by-count":43,"title":["Concomitant twice\u2010a\u2010day radiotherapy and chemotherapy in unresectable head and neck cancer patients: A long\u2010term quality of life analysis"],"prefix":"10.1002","volume":"23","author":[{"given":"Nicolas","family":"Magn\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Yves","family":"Marcy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Chamorey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Guardiola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Pivot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Demard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9\u2010Jean","family":"Bensadoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00235-1"},{"issue":"8","key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1200\/JCO.2000.18.8.1652","article-title":"Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer","volume":"18","author":"Vokes EE","year":"2000","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.24.2065"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.24.2081"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1318"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806183382503"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90670-Y"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.3.329"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90104-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199705)19:3<169::AID-HED1>3.0.CO;2-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.4.459"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050010"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050256"},{"key":"e_1_2_1_15_2","first-page":"346","article-title":"Mise au point d'un autoquestionnaire de qualit\u00e9 de vie sp\u00e9cifique des tumeurs des voies a\u00e9rodigestives sup\u00e9rieures","volume":"44","author":"Schraub S","year":"1996","journal-title":"Rev Epidem Sant\u00e9 Publique"},{"key":"e_1_2_1_16_2","first-page":"191","volume-title":"Evaluation of Chemotherapeutic Agents: Symposium, Microbiology Section, New York Academy of Medicine","author":"Karnofsky DA","year":"1949"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00558-1"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00079-0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.1020"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<288::AID-HED12>3.0.CO;2-B"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200001000-00018"}],"container-title":["Head &amp; 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