{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:36:55Z","timestamp":1777343815820,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2001,8,8]],"date-time":"2001-08-08T00:00:00Z","timestamp":997228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carotid artery stenosis is a late complication of radiotherapy to the neck region. This complication has, however, a significant impact with increased risk of stroke causing mortality and morbidity. Clinicians' awareness of this complication and early detection is therefore important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients with nasopharyngeal carcinoma (NPC) who had received radiotherapy were recruited for color Doppler ultrasonography of the carotid arteries. fifty\u2010eight patients with newly diagnosed NPC who had never received any radiotherapy were recruited as controls. All patients with significant carotid stenosis were referred to the neurology clinic for further assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients were found to have more than 50% diameter reduction in the extracranial carotid artery. Clinical assessment by a neurologist showed 9 of 24 patients had a history of transient ischemic attack, amaurosis fugax, or stroke. Seven of these patients had clinically detectable neck bruit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinicians attending to patients after radiotherapy for head and neck cancers should be aware of this long\u2010term complication of radiotherapy. A detailed clinical history and incorporation of auscultation of carotid arteries in routine follow\u2010up of postradiotherapy patients are recommended. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 780\u2013784, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1111","type":"journal-article","created":{"date-parts":[[2004,11,14]],"date-time":"2004-11-14T11:38:49Z","timestamp":1100432329000},"page":"780-784","source":"Crossref","is-referenced-by-count":53,"title":["Clinically underdetected asymptomatic and symptomatic carotid stenosis as a late complication of radiotherapy in Chinese nasopharyngeal carcinoma patients"],"prefix":"10.1002","volume":"23","author":[{"given":"Wynnie Wai\u2010man","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hok\u2010yuen","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka\u2010sing","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sing\u2010fai","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin\u2010hung","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine","family":"Metreweli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"382","article-title":"Nasopharyngeal cancer: epidemiology, staging, and treatment","volume":"21","author":"Fandi A","year":"1994","journal-title":"Semin Oncol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(96)90254-2"},{"key":"e_1_2_1_4_2","first-page":"297","article-title":"Foam cell plaques in the intima of irradiated small arteries (one hundred to five hundred microns in external diameter)","volume":"37","author":"Sheehan JF","year":"1944","journal-title":"Arch Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-75-18369"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.10.1.51"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197801)41:1<130::AID-CNCR2820410121>3.0.CO;2-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100305"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)39688-8"},{"key":"e_1_2_1_10_2","first-page":"2943","article-title":"Radiation\u2010induced damage of the carotid artery as a cause of transitory ischemic attacks","volume":"83","year":"1986","journal-title":"Lakartidningen"},{"key":"e_1_2_1_11_2","first-page":"320","article-title":"Radiation\u2010induced vasculopathy of the carotid artery and vertebral artery","volume":"37","author":"Steiner H","year":"1984","journal-title":"Rontgen\u2010Blatter"},{"key":"e_1_2_1_12_2","first-page":"3","article-title":"Arterial stenosis after radiotherapy","volume":"77","author":"Calitchi E","year":"1990","journal-title":"Bull Cancer Radiother"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.213.1.r99oc07167"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198111000-00009"},{"key":"e_1_2_1_15_2","first-page":"306","article-title":"Radiation\u2010induced arterial injuries","volume":"93","author":"McCready RA","year":"1983","journal-title":"Surgery"},{"key":"e_1_2_1_16_2","first-page":"24","article-title":"Radiation\u2010induced damage to the large arteries","volume":"35","author":"Bootz F","year":"1987","journal-title":"HNO"},{"key":"e_1_2_1_17_2","first-page":"165","article-title":"Doppler sonography of the carotid arteries in patients treated by radiation after laryngectomy","volume":"40","author":"Pancic B","journal-title":"Neurologica Croatica"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.71.848.9828801"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520400109029"},{"key":"e_1_2_1_20_2","first-page":"9","article-title":"Arterial lesions after radiotherapy in children. Apropos of 16 cases","volume":"50","author":"Ganry O","year":"1993","journal-title":"Arch Francaises Pediatr"},{"key":"e_1_2_1_21_2","first-page":"269","article-title":"Fifty\u2010three atherosclerotic carotid stenoses in an irradiated environment","volume":"18","author":"Cormier JM","year":"1993","journal-title":"J Maladies Vasculaires"},{"key":"e_1_2_1_22_2","first-page":"56","article-title":"Injury of the large vessels of the neck caused by radiation of neoplasms of the otorhinolaryngologic region: a study using Doppler echography","volume":"80","author":"Cugini G","year":"1990","journal-title":"Radiol Med"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.1999.0884"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050694"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870230206"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.0442f.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022646204200"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70374-5"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70100-X"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.38.suppl_268"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70351-4"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100169900002"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.1111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.1111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:00:30Z","timestamp":1696186830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.1111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,8]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1002\/hed.1111"],"URL":"https:\/\/doi.org\/10.1002\/hed.1111","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,8]]}}}