{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:41:45Z","timestamp":1784860905856,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,9,5]],"date-time":"2001-09-05T00:00:00Z","timestamp":999648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both surgery and radiotherapy are recognized treatments of T1\u2010T2 squamous cell carcinoma of the larynx. We retrospectively analyze and compare the oncological outcome of patients treated in a single institution, either by endoscopic surgery or partial supracricoid laryngectomy versus radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 156 patients treated between 1983 and 1996 with either surgery (<jats:italic>n<\/jats:italic>= 75) or radiotherapy (<jats:italic>n<\/jats:italic>= 81) were reviewed. Male to female ratio, median age, and T\u2010stage distribution were comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up time of 59 months, the 5\u2010year cause\u2010specific survival rate of 93% was identical for both groups. The actuarial incidence of metachronous second primaries was 7% at 5 years. Local control at 5 years remained 84% after surgery and 77% after radiotherapy. Anterior commissure infiltration was shown to represent a negative predictive factor of local control for radiotherapy (<jats:italic>p<\/jats:italic>= .01). Salvage treatment brought ultimate local control to 96% of patients after surgery and 94% after radiation therapy with long\u2010term laryngeal preservation rate altered significantly (<jats:italic>p<\/jats:italic>= .05) in the group of patients who received radiotherapy (90.1% vs 97.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The treatment of laryngeal cancer is always a compromise between oncological efficiency and preservation of function. Our data suggest that, assuming proper selection of patients, radiation therapy and surgery yield similar local control and survival rates. The functional disadvantages after surgery are moderate and clearly counterbalanced by a significant decrease in long\u2010term laryngeal preservation rate after radiotherapeutic treatment. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 823\u2013829, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1120","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:44:49Z","timestamp":1030308289000},"page":"823-829","source":"Crossref","is-referenced-by-count":60,"title":["Treatment of early stage squamous\u2010cell carcinoma of the glottic larynx: Endoscopic surgery or cricohyoidoepiglottopexy versus radiotherapy"],"prefix":"10.1002","volume":"23","author":[{"given":"Lue 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