{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:53:59Z","timestamp":1783522439290,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,9,5]],"date-time":"2001-09-05T00:00:00Z","timestamp":999648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to assess the effectiveness of free tissue transfer for treatment of advanced mandibular osteoradionecrosis (ORN) in head and neck cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 29 patients who were treated for advanced mandibular ORN by radical resection and reconstruction with free flaps at our institution. All patients had either failed to respond to conservative treatment, including hyperbaric oxygen therapy and debridement or had pathological fracture due to ORN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four vascularized bone (17 fibula, five iliac, and two scapula), four rectus abdominis myocutaneous, and one radial forearm fasciocutaneous free flaps were used. The complications occurred in 6 of 29 patients (21%). A total of four flaps (14%) were lost. The mean follow\u2010up was 2 years 9 months. All patients had complete resolution of ORN symptoms. No evidence of ORN recurrence was observed in any patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For advanced osteoradionecrosis of the mandible, radical resection followed by reconstruction using free flap provides a reliable means of obtaining good wound healing with acceptable aesthetic and functional results. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 830\u2013835, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1121","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:44:49Z","timestamp":1030308289000},"page":"830-835","source":"Crossref","is-referenced-by-count":98,"title":["Management of advanced mandibular osteoradionecrosis with free flap reconstruction"],"prefix":"10.1002","volume":"23","author":[{"given":"David W.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010kyun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey L.","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,9,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199708)19:5<406::AID-HED7>3.0.CO;2-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000426"},{"key":"e_1_2_1_4_2","first-page":"861","article-title":"Intra\u2010oral mandibular resections for osteoradionecrosis","volume":"31","author":"Freestone JT","year":"1973","journal-title":"J Oral Surg"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(74)90042-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90136-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197606)37:6<2580::AID-CNCR2820370603>3.0.CO;2-H"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199808)20:5<411::AID-HED9>3.0.CO;2-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199908000-00027"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(95)80009-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199306000-00005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90314-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100112551"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(78)80103-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(99)90013-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844319609056407"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860040087025"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199804040-00006"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930240409"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197501000-00007"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198512000-00005"},{"key":"e_1_2_1_22_2","first-page":"755","article-title":"Timing, results, and complications of mandibular reconstructive surgery: report of 32 cases","volume":"37","author":"Adamo AK","year":"1979","journal-title":"J Oral Surg"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(98)90709-1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198404000-00014"},{"key":"e_1_2_1_25_2","unstructured":"GallasMT MillerMJ.Flap selection for optimal functional and aesthetic outcome in posterior mandible reconstruction. 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