{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:34:07Z","timestamp":1790937247859,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2001,10,5]],"date-time":"2001-10-05T00:00:00Z","timestamp":1002240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this investigation was to determine whether F18\u2010fluoro\u2010deoxy\u2010glucose (FDG) positron\u2010emission tomography (PET) could differentiate between local recurrence and late radiation effects after radiotherapy for laryngeal\/pharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective study of 75 patients (67 larynx, eight oro\/hypopharynx), 160 laryngoscopies and 109 FDG PET scans were performed on the head and neck region. The mean follow\u2010up time after the first FDG PET scan was 23 months (minimum 1 year).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Local recurrence was diagnosed in 37 patients: 19 after the first biopsy and 18 after follow\u2010up biopsies. For all of the negative initial FDG scans (27), the biopsies that were taken at the same time were negative and no recurrence was seen for at least 1 year. The first FDG scan was a true positive in 34 of 48 patients. In 12 of the 14 patients with false\u2010positive results, FDG scans were repeated; a decreased FDG uptake was found in 9 of the 12. The sensitivity and specificity of the first scan were respectively 92% and 63%; including subsequent FDG scans, the rates were 97% and 82%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When a local recurrence is suspected after radiotherapy for cancer of the larynx\/pharynx, an FDG PET scan should be the first diagnostic step. No biopsy is needed if the scan is negative. If the scan is positive and the biopsy negative, a decreased FDG uptake measured in a follow\u2010up scan indicates that a local recurrence is unlikely. \u00a9 2001 John Wiley &amp; Sons, Inc. Head Neck 23: 933\u2013941, 2001.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1135","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T22:20:22Z","timestamp":1031696422000},"page":"933-941","source":"Crossref","is-referenced-by-count":137,"title":["F\u201018\u2010fluoro\u2010deoxy\u2010glucose positron\u2010emission tomography scanning in detection of local recurrence after radiotherapy for laryngeal\/ pharyngeal cancer"],"prefix":"10.1002","volume":"23","author":[{"given":"Chris H.","family":"Terhaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Bongers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"van Rijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit\u2010Jan","family":"Hordijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,10,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90274-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(90)90112-A"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90229-W"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841868809090339"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0030-6665(20)31970-8","article-title":"The effect of radiation on connective tissue","volume":"17","author":"Moore MJ","year":"1984","journal-title":"Otolaryngol Clin N Am"},{"key":"e_1_2_1_7_2","first-page":"665","article-title":"The significance of laryngeal edema following radiotherapy of carcinoma of the vocal cord","volume":"94","author":"Fu KK","year":"1982","journal-title":"Am Cancer Soc"},{"key":"e_1_2_1_8_2","unstructured":"TerhaardCHJ HordijkGJ DolsmaWV HilgersFJM Tjho\u2010HeslingaRE ManniJJ KnegtPPM CrollGA.Morbidity associated with treatment for T3 laryngeal cancer. Laryngeal Cancer Proceedings of the 2nd World Congress on Laryngeal Cancer1994;561\u2010565."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-63-751-554"},{"key":"e_1_2_1_10_2","first-page":"590","article-title":"Histological changes of the human larynx irradiated with various technical therapeutic methods","volume":"79","author":"Manara M","year":"1966","journal-title":"Arch Ital Otolaryngol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00421-G"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198303000-00013"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1992.tb01681.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100097620"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197503000-00009"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910201)67:3<577::AID-CNCR2820670309>3.0.CO;2-W"},{"key":"e_1_2_1_17_2","first-page":"1385","article-title":"Fluorine\u201018\u2010FDG detection of laryngeal cancer postradiotherapy using dual\u2010head coincidence imaging","volume":"39","author":"Stokkel MP","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050448"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(96)80529-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700406"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1988.tb00320.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(05)80089-9"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01249629"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199802000-00002"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.186.1.8416578"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880501)61:9<1776::AID-CNCR2820610909>3.0.CO;2-7"},{"key":"e_1_2_1_27_2","first-page":"1655","article-title":"Assessment of response to cancer therapy using fluorine\u201018\u2010fluorodeoxyglucose and positron emission tomography","volume":"32","author":"Ichiya Y","year":"1991","journal-title":"J Nucl Med"},{"key":"e_1_2_1_28_2","first-page":"1521","article-title":"Evaluation of treatment response to radiotherapy in head and neck cancer with fluorine\u201018 fluorodeoxyglucose","volume":"29","author":"Minn H","year":"1988","journal-title":"J Nucl Med"},{"key":"e_1_2_1_29_2","first-page":"1548","article-title":"Glucose uptake, perfusion and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry","volume":"32","author":"Haberkorn U","year":"1991","journal-title":"J Nucl Med"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90259-X"},{"key":"e_1_2_1_31_2","first-page":"53","article-title":"Initial coincidence imaging experience with SPECT\/PET dual head camera","volume":"37","author":"Glass EC","year":"1996","journal-title":"J Nucl Med"},{"key":"e_1_2_1_32_2","article-title":"Performance characteristics of dual head SPECT scanner with PET capability","author":"Nellemann PHH","year":"1995","journal-title":"IEEE Nuclear Science Symposium"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(99)00003-0"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199907000-00004"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00024"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00007"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332162"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050290"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165391"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880120106"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400403"},{"key":"e_1_2_1_42_2","first-page":"2121","article-title":"Coregistration of FDG PET and MRI of the head and neck using normal distribution of FDG","volume":"39","author":"Uematsu H","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_1_43_2","first-page":"256","article-title":"FDG uptake in tonsils","volume":"39","author":"Kawabe J","year":"1998","journal-title":"J Nucl Med"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.1135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.1135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T14:53:47Z","timestamp":1700405627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.1135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,5]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1002\/hed.1135"],"URL":"https:\/\/doi.org\/10.1002\/hed.1135","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,5]]}}}