{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:17:15Z","timestamp":1759515435455},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,11,19]],"date-time":"2001-11-19T00:00:00Z","timestamp":1006128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Development of a second primary squamous cell carcinoma in the skin of a flap used for pharyngeal reconstruction is rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case of squamous cell carcinoma is presented arising in a deltopectoral flap used to reconstruct the hypopharynx 27 years after total laryngectomy. Three previous reports found on review of the literature are summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A second primary squamous cell carcinoma may arise in the skin of a myocutaneous flap in the absence of any obvious risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suspect that long\u2010term exposure of the skin of the flap lining the pharynx to saliva may have been a significant factor in the development of this malignancy. Long\u2010term follow up and awareness of this complication is required for patients with soft tissue reconstruction of the oral cavity and pharynx. \u00a9 2002 John Wiley &amp; Sons, Inc. Head Neck 24: 87\u201390, 2002.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.1154","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T00:30:33Z","timestamp":1098923433000},"page":"87-90","source":"Crossref","is-referenced-by-count":16,"title":["Squamous cell carcinoma arising in the skin of a deltopectoral flap 27 years after pharyngeal reconstruction"],"prefix":"10.1002","volume":"24","author":[{"given":"Tim A.","family":"Iseli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis T.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm R.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Kleid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,20]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196508000-00004"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198307000-00015"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1983.00800260034008"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1998)11:6<379::AID-CA3>3.0.CO;2-H"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(95)00041-0"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)31838-7"},{"key":"e_1_2_4_8_2","first-page":"1170","volume-title":"Robbins pathological basis of disease","author":"Murphy GF","year":"1999"},{"key":"e_1_2_4_9_2","first-page":"178","article-title":"Irradiation\u2010induced tumours of the head and neck","volume":"360","author":"Aanesen JP","year":"1979","journal-title":"Acta Oto\u2010Laryngol Suppl"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000027587"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100114021"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(92)90121-D"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1983.00800200053014"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.1154","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.1154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T11:11:55Z","timestamp":1700392315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.1154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,20]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1002\/hed.1154"],"URL":"https:\/\/doi.org\/10.1002\/hed.1154","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,20]]}}}