{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:14:38Z","timestamp":1785338078905,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T00:00:00Z","timestamp":1089331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>We evaluated the functional and oncologic results of supraglottic hemipharyngolaryngectomy as treatment for T1 and T2 lateral laryngeal margin and piriform sinus carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Eighty\u2010seven patients underwent this surgical treatment. The disease was classified T1 in 14 of these cases (16.1%) and T2 in 73 cases (83.9%). The nodal status indicated 39 cases of N0 (44.8%), 18 cases of N1 (20.7%), 28 cases of N2 (32.2%), and two cases of N3 (2.2%). With regard to the N0 cases, 15 (38.4%) were positive at the histologic examination. Within the N+ group, 52.1% involved capsular rupture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Two patients died of complications during the postoperative period. The mean duration of nasogastric tube feeding was 20 days. Six patients (7.27%) had feeding resumption problems. All patients were decanulated after a mean period of 16 days. All patients underwent postoperative radiation therapy, except two with T1N0N\u2212 disease and three who had previously undergone this treatment. The 5\u2010year actuarial survival rate was 60.3% (T1, 83.3%; T2, 49.9%). The rates of local and regional recurrence, second primary cancer, and metastasis were 19.5%, 24.1%, and 28.1%, respectively. The infringement of the pharyngoepiglottic fold was significantly correlated with locoregional recurrence. The survival rate was significantly correlated with the nodal status and extracapsular spread.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Initial staged cancers of the laryngeal margin and piriform sinus can be successfully managed with conservative surgery called supraglottic hemipharyngolaryngectomy combined with nodal neck dissection. Postoperative radiation therapy is still recommended in most cases because of the high recurrence potential and prevalence of secondary regional cancers. This combined treatment seems to be a suitable therapeutic choice in the treatment of patients with T1 and T2 carcinomas of the laryngeal margins and piriform sinus. \u00a9 2004 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>26:<\/jats:bold> 701\u2013705, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20051","type":"journal-article","created":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T19:02:54Z","timestamp":1089399774000},"page":"701-705","source":"Crossref","is-referenced-by-count":26,"title":["Supraglottic hemipharyngolaryngectomy for the treatment of T1 and T2 carcinomas of laryngeal margin and piriform sinus"],"prefix":"10.1002","volume":"26","author":[{"given":"Marc","family":"Makeieff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiseppe","family":"Mercante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elh\u00e1m","family":"Jouzdani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Garrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Crampette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Guerrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199611\/12)18:6<494::AID-HED2>3.0.CO;2-Y"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880170503"},{"key":"e_1_2_6_4_2","first-page":"633","article-title":"Conservative surgery of cancer of the larynx","volume":"51","author":"Alonso JM","year":"1947","journal-title":"Trans Am Acad Opthalmol Otorynolaryngol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199108000-00011"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199301000-00015"},{"key":"e_1_2_6_7_2","first-page":"229","article-title":"Les traitements des cancers de la margelle laryng\u00e9e \u00e0 propos de 200 cas","volume":"34","author":"Piquet JJ","year":"1985","journal-title":"J Fr Orl"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198412000-00010"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197511000-00001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197510000-00006"},{"key":"e_1_2_6_11_2","first-page":"995","article-title":"Les \u00e9pitheliomas de la margelle lat\u00e9rale","volume":"12","author":"Laccoureye H","year":"1980","journal-title":"Ann Otol Laryngol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890050609"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0924-4212(96)85313-8"},{"key":"e_1_2_6_14_2","first-page":"27","article-title":"Les cancers de la margelle laryng\u00e9e. 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