{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:52:42Z","timestamp":1761742362034},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T00:00:00Z","timestamp":1084320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>The purpose of this study was to investigate the frequency of Epstein\u2010Barr virus (EBV) latent membrane protein\u20101 (<jats:italic>LMP\u20101<\/jats:italic>) in tonsils and non\u2010neoplastic nasopharynxes in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Nest\u2010polymerase chain reaction (nest\u2010PCR) was used to examine the presence of <jats:italic>LMP\u20101<\/jats:italic> gene in lymphoid hyperplasia from non\u2010neoplastic tonsillar and nasopharyngeal tissues and in tonsillar cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In 152 cases, 64 biopsy tissues were obtained from lymphoid hyperplasia of nasopharynxes, 57 from tonsillectomy of non\u2010neoplastic tonsils, and 31 from tonsillar cancers. <jats:italic>LMP\u20101<\/jats:italic> was detected in 43.4% of the study group. Nineteen (29.7%) and 29 (50.9%) lymphoid hyperplasias from normal nasopharynxes and tonsils, respectively, and 18 (58.1%) biopsies from tonsillar cancers had positive <jats:italic>LMP\u20101<\/jats:italic>. The 30\u2013base pair (bp) deleted variant was detected in 89.5% and 82.8% of normal nasopharynxes and tonsils, respectively, and in 66.7% of biopsies from tonsillar cancers (<jats:italic>p<\/jats:italic> = .198).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This study found that the 30\u2010bp variant was the predominant type of <jats:italic>LMP\u20101<\/jats:italic> from a healthy population in Taiwan. \u00a9 2004 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>26:<\/jats:bold> 619\u2013624, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20057","type":"journal-article","created":{"date-parts":[[2004,5,12]],"date-time":"2004-05-12T21:08:40Z","timestamp":1084396120000},"page":"619-624","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of <i>LMP\u20101<\/i> gene in tonsils and non\u2010neoplastic nasopharynxes by nest\u2010polymerase chain reaction in Taiwan"],"prefix":"10.1002","volume":"26","author":[{"given":"Ping\u2010Ching","family":"Pai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngan\u2010Ming","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Kan","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Po","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tseng\u2010Tong","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Chen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuen","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Cheng","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,12]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199612000-00012"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.12.4053.bloodjournal84124053"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1182\/blood.V89.5.1723","article-title":"Epstein\u2010Barr 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