{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:56:48Z","timestamp":1788580608749,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T00:00:00Z","timestamp":1096502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Transoral CO<jats:sub>2<\/jats:sub> laser surgery (TLS) has demonstrated good oncologic results and low morbidity in the treatment of selected laryngeal carcinomas, but experience in hypopharyngeal carcinomas (HC) is limited. The aim of this study was to evaluate the usefulness of TLS in the treatment of selected HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Twenty\u2010eight patients with HC were treated with TLS and neck dissection. Tumors with preoperative invasion of thyroid cartilage at CT, deep growth into the cervical space or tongue base, and tumors crossing the posterior midline or involving the cervical esophagus were excluded. Postoperative radiation to the neck was administered when more than one lymph node was involved, when the metastasis diameter was greater than 2 cm, or when extranodal spread was found at the pathologic study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The sample included two T1, 16 T2, nine T3, and one T4 tumors. Stage classification was: II, 21.4%; III, 28.6%; and IV, 50%. Four\u2010year overall and disease\u2010specific survival rates were 43.4% and 59.4%, respectively, with 78.5% function preservation. Nine patients (32.1%) did not need a nasogastric feeding tube. The mean duration of the feeding tube in the remaining patients was 15.27 \u00b1 27.3 days. We had two postoperative bleeding episodes that required endoscopic coagulation and three postoperative pneumonias caused by aspiration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>TLS is an alternative for the treatment of selected HC associated with a high larynx preservation rate. \u00a9 2004 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>26:<\/jats:bold> 953\u2013959, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20074","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T19:16:25Z","timestamp":1099422985000},"page":"953-959","source":"Crossref","is-referenced-by-count":58,"title":["CO<sub>2<\/sub> laser surgery: A larynx preservation alternative for selected hypopharyngeal carcinomas"],"prefix":"10.1002","volume":"26","author":[{"given":"Isabel","family":"Vilaseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Blanch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Bernal\u2010Sprekelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Moragas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.115060"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.136.10.1164"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000227659"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/028418600750013465"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1258\/0022215021910294"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1995.tb01860.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90011-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200012000-00019"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.13.890"},{"key":"e_1_2_5_11_2","first-page":"1","article-title":"Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local\u2010regional treatment in piriform sinus cancer","volume":"82","author":"Grau JJ","year":"1996","journal-title":"Tumori"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<595::AID-HED2>3.0.CO;2-J"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.4.384"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.2.142"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100606"},{"key":"e_1_2_5_16_2","volume-title":"Endoscopic laser surgery of the upper aerodigestive tract","author":"Steiner W","year":"2000"},{"key":"e_1_2_5_17_2","series-title":"Head and neck surgery","first-page":"355","author":"Rudert H","year":"1998"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.11.1245"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200006000-00022"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1998)23:2<79::AID-LSM5>3.0.CO;2-S"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199401000-00012"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.103.977"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-8771"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s00405-002-0520-8","article-title":"Transoral carbon\u2010dioxide laser resection of hypopharynx carcinoma","volume":"260","author":"Rudert HH","year":"2003","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.111597"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10363"},{"key":"e_1_2_5_27_2","first-page":"17","volume-title":"UICC International Union Against Cancer TNM classification of malignant tumors","author":"Sobin LH","year":"1997"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199701)19:1<1::AID-HED1>3.0.CO;2-A"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199312000-00010"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70240-7"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00015"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10207"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200106000-00028"},{"key":"e_1_2_5_34_2","first-page":"149","article-title":"Second primary tumors in patients with carcinoma of the head and neck","volume":"51","author":"Herranz Gonzalez\u2010Botas J","year":"2000","journal-title":"Acta Otorrinolaringol Esp"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100201"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199905)21:3<204::AID-HED4>3.0.CO;2-7"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10444"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T03:24:11Z","timestamp":1700191451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,27]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/hed.20074"],"URL":"https:\/\/doi.org\/10.1002\/hed.20074","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,27]]}}}