{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:19:07Z","timestamp":1769606347599,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T00:00:00Z","timestamp":1096502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Residual structural abnormalities after definitive treatment of head and neck squamous cell carcinoma (HNSCC) are common and pose difficult management problems. The usefulness of fluorine\u201018 fluorodeoxyglucose positron emission tomography (FDG PET) to supplement conventional evaluation with clinical and standard radiologic examination (CE) in such patients was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Fifty\u2010three eligible patients were identified with residual structural abnormalities on CE. True disease extent could be validated in 46 patients. Patients had a median potential follow\u2010up of 55 months (range, 41\u201375 months) from the date of PET scan to the analysis closeout date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>PET had better diagnostic accuracy than CE (<jats:italic>p<\/jats:italic> = .0002) and induced management change in 21 patients (40%; 95% confidence interval [CI], 26%\u201354%), including avoidance of unnecessary planned surgery in 14 patients with negative PET. Appropriate management change was confirmed in 19 (95%) of 20 evaluable cases. Disease presence and extent assessment by PET were significant predictors of survival (<jats:italic>p<\/jats:italic> &lt; .0001), whereas the extent of disease determined by CE was not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>PET added significantly to the value of CE in restaging disease in patients with structural abnormalities after definitive treatment of HNSCC. Management decisions based on PET were appropriate in most patients. \u00a9 2004 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>26:<\/jats:bold> 1008\u20131017, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20097","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T23:03:48Z","timestamp":1096585428000},"page":"1008-1017","source":"Crossref","is-referenced-by-count":57,"title":["Usefulness of fluorine\u201018 fluorodeoxyglucose positron emission tomography in patients with a residual structural abnormality after definitive treatment for squamous cell carcinoma of the head and neck"],"prefix":"10.1002","volume":"26","author":[{"given":"Robert E.","family":"Ware","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane P.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Porceddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Rischin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Corry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"25","article-title":"Treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck: current status and future directions","volume":"27","author":"Khuri FR","year":"2000","journal-title":"Semin Oncol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.24.2065"},{"key":"e_1_2_6_4_2","first-page":"91","article-title":"Nuclear medicine in head and neck oncology: reality and perspectives","volume":"40","author":"Chisin R","year":"1999","journal-title":"J Nucl Med"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050293"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.197.1.7568825"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.200.1.8657901"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199805)20:3<208::AID-HED5>3.0.CO;2-4"},{"key":"e_1_2_6_9_2","first-page":"617","article-title":"Continuous\u2010slice PENN\u2010PET: a positron tomograph with volume imaging capability","volume":"31","author":"Karp JS","year":"1990","journal-title":"J Nucl Med"},{"key":"e_1_2_6_10_2","first-page":"173","article-title":"Standards for performance measurements of PET scanners\u2014evaluation with the UGM PENN\u2010PET 240H scanner","volume":"17","author":"Karp JS","year":"1991","journal-title":"Med Progr Technol"},{"key":"e_1_2_6_11_2","first-page":"1257","article-title":"Clinical evaluation of processing techniques for attenuation correction with 137Cs in whole body PET imaging","volume":"40","author":"Benard F","year":"1999","journal-title":"J Nucl Med"},{"key":"e_1_2_6_12_2","volume-title":"StatXact","year":"2001"},{"key":"e_1_2_6_13_2","volume-title":"S\u2010Plus 2000","year":"1999"},{"key":"e_1_2_6_14_2","volume-title":"SPSS for Windows","year":"2000"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.6.9393187"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00037-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.651"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00148-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<606::AID-HED4>3.0.CO;2-G"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502163320704"}],"container-title":["Head &amp; 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