{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:23:19Z","timestamp":1760980999454},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T00:00:00Z","timestamp":1133308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Induction of angiogenesis is a key process in tumor growth and metastasis. We studied the CD105 (endoglin) and vascular endothelial growth factor (VEGF) in hypopharyngeal cancer to evaluate their clinicopathologic significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Seventy\u2010three patients who underwent complete excision of hypopharyngeal cancer were included in this study. Clinicopathologic data were collected retrospectively. Immunohistochemical analysis was performed with antibodies of CD105 and VEGF. Positive\u2010stained microvessels for CD105 were counted on hot spots of tumors. The staining intensity for VEGF was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>High expression of CD105 correlated significantly with positive nodal metastasis (<jats:italic>p<\/jats:italic> &lt; .001) and TNM stage (<jats:italic>p<\/jats:italic> &lt; .01). High expression of VEGF correlated significantly with advanced tumor (T) classification (<jats:italic>p<\/jats:italic> &lt; .01). The overall 5\u2010year survival rate was worse in patients with higher CD105 expression (<jats:italic>p<\/jats:italic> &lt; .001), advanced TNM stage (<jats:italic>p<\/jats:italic> &lt; .01), advanced T classification (<jats:italic>p<\/jats:italic> &lt; .01), and positive nodal metastasis (<jats:italic>p<\/jats:italic> &lt; .001). Furthermore, Cox regression analysis revealed that CD105 expression in microvessels of tumor tissue, advanced T classification, and nodal status were independent factors for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our results suggest that expression of CD105 is a useful predictive prognostic factor in hypopharyngeal cancer. \u00a9 2005 Wiley Periodicals, Inc. <jats:italic>Head Neck<\/jats:italic> <jats:bold>28:<\/jats:bold> 441\u2013446, 2006<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20364","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T17:55:04Z","timestamp":1133459704000},"page":"441-446","source":"Crossref","is-referenced-by-count":33,"title":["Clinicopathologic significance of CD105 expression in squamous cell carcinoma of the 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