{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:52:06Z","timestamp":1791978726202,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T00:00:00Z","timestamp":1150675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Although the lateral pharyngotomy is a well\u2010known surgical procedure, to our knowledge, no published reports have described the results achieved with a lateral pharyngectomy approach in patients with isolated and previously untreated selected invasive squamous cell carcinoma of the lateral wall of the pyriform sinus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The medical files and operative charts of 30 patients with an isolated, and previously untreated, squamous cell carcinoma of the pyriform sinus, treated for cure by lateral partial pharyngectomy and primary closure, as well as postoperative radiotherapy (<jats:italic>n<\/jats:italic> = 22), and preoperative chemotherapy (<jats:italic>n<\/jats:italic> = 8), were retrospectively studied. Sixteen tumors were classified as T1 and 14 as T2. All patients but one were followed until death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Three patients (9%) died in the immediate postoperative period (two from medical complications and one from a surgery\u2010related complication). Overall, 29 patients died, resulting in a 77.7%, 40%, 23.3%, and 15% 1\u2010, 3\u2010, 5\u2010 and 10\u2010year Kaplan\u2013Meier actuarial survival estimate, respectively. Only one patient had a serious postoperative complication develop. All patients were decannulated. No patients required a gastrostomy and\/or completion total laryngectomy for functional reasons. Local recurrence occurred in four patients (13%). The 3\u2010and 5\u2010year Kaplan\u2013Meier actuarial local control estimates were 88.5% and 79.6%, respectively. The use of a platin\u2010based induction chemotherapy (<jats:italic>p<\/jats:italic> = .05) regimen was the only variable that was significantly statistically related to local recurrence. Overall, a 93.3% laryngeal preservation rate was achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Partial pharyngectomy by means of the lateral pharyngotomy combined with postoperative radiation therapy is an efficient and function\u2010sparing approach to control selected invasive squamous cell carcinomas of the lateral wall of the pyriform sinus. \u00a9 2006 Wiley Periodicals, Inc. Head Neck, 2006<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20375","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T23:04:24Z","timestamp":1150758264000},"page":"705-711","source":"Crossref","is-referenced-by-count":32,"title":["Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: The partial lateral pharyngectomy"],"prefix":"10.1002","volume":"28","author":[{"given":"F. 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