{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:31:23Z","timestamp":1790458283205,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>We investigated the application of boron neutron capture therapy (BNCT) to suitable cancers other than glioblastoma and melanoma. Head and neck malignancies were consequently selected as adaptable cancers. We reported the clinical results of our first case treated and discussed several advantages to the application of BNCT to head and neck tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The patient was a 48\u2010year\u2010old woman with recurrent submandibular gland cancer. We confirmed the p\u2010boronophenylalanine (BPA)\u2010accumulating capacity of the tumor by fluorine\u201018\u2010labeled p\u2010boronophenylalanine positron emission tomography (<jats:sup>18<\/jats:sup>F\u2010BPA PET) before BNCT. The tumor\/normal tissue boron concentration ratio was 2.9. The patient underwent a preirradiation CT scan for treatment planning performed using the \u201cSERA\u201d software program. The tumor was irradiated at the Kyoto University Research Reactor with epithermal neutrons 5 MW for 90 minutes. The tumor dose and normal tissue dose calculated ranged from 20.0 to 25.2 Gy and from 3.2 to 5.8 Gy, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>To date there has been continuous complete regression in the tumor and no acute and chronic complications for 1.5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Although only 1 patient has shown complete regression and additional long\u2010term follow\u2010up should be required to assess this treatment, we believe that head and neck tumors are suitable for BNCT and that such excellent results will have a great impact on patients in the near future. \u00a9 2006 Wiley Periodicals, Inc. Head Neck, 2006<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20418","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T18:02:03Z","timestamp":1148407323000},"page":"850-855","source":"Crossref","is-referenced-by-count":140,"title":["First clinical case of boron neutron capture therapy for head and neck malignancies using <sup>18<\/sup>F\u2010BPA PET"],"prefix":"10.1002","volume":"28","author":[{"given":"Teruhito","family":"Aihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Hiratsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Maruhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"215","article-title":"Neutron capture treatment of malignant melanoma using 10B\u2010chlorpromazine","volume":"1","author":"Mishima Y","year":"1973","journal-title":"Pigment Cell Res"},{"key":"e_1_2_5_3_2","first-page":"127","article-title":"Improvement of solubility of p\u2010boronophenylalanine by complex formation with monosaccharides","volume":"165","author":"Yoshino K","year":"1989","journal-title":"Strahlenther Oncol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2307\/3578136"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1989.tb00196.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90567-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2004.05.059"},{"key":"e_1_2_5_8_2","first-page":"1833","article-title":"Positron emission tomography\u2010based boron neutron capture therapy using boronophenylalanine for high\u2010grade gliomas. 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