{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:12:21Z","timestamp":1792059141117,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Surgery for squamous cell carcinoma (SCC) arising or extending to the hypopharynx is generally reserved for advanced disease or salvage. The prognosis of patients requiring pharyngectomy is poor, and the perioperative morbidity is significant. The aim of the present study is to describe the disease\u2010related and treatment\u2010related outcomes of patients undergoing primary and salvage pharyngectomy for cancer of the hypopharynx and larynx over a 10\u2010year period from a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We retrospectively reviewed 138 partial and circumferential pharyngectomies performed at a tertiary referral center between 1992 and 2002. There were 31 females and 107 males. The median age was 62 years (range, 27\u201381 years), and mean follow\u2010up was 3.6 years. Salvage pharyngectomy for radiation failure was performed in 72 patients (52%), and in 66 patients (48%) pharyngectomy was performed as the primary treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The 5\u2010year overall survival rate after salvage pharyngectomy was 31% and after primary pharyngectomy was 38%. The 5\u2010year disease\u2010specific survival (DSS) for salvage was 40% and after primary surgery was 45%. The 5\u2010year local and regional control rates for salvage pharyngectomy were 71% and 70%, respectively, and for primary pharyngectomy were 79% and 67%, respectively. The perioperative mortality rate was 3.6%, and the combined morbidity rate was 70%. Postoperative hypocalcemia developed in 44% of patients, a pharyngocutaneous fistula developed in 31% of patients, and the long\u2010term stricture rate was 15%. Variables adversely affecting DSS on univariate analysis were nodal metastases (<jats:italic>p<\/jats:italic> = .044), extracapsular spread (ECS) (<jats:italic>p<\/jats:italic> = .006), poorly differentiated tumors (<jats:italic>p<\/jats:italic> = .015), lymphovascular invasion (<jats:italic>p<\/jats:italic> = .042), and positive tumor margins (<jats:italic>p<\/jats:italic> = .026). ECS (<jats:italic>p<\/jats:italic> = .023) was the only independent prognostic variable on multivariable analysis; however, there was a trend toward significance for nodal metastases (<jats:italic>p<\/jats:italic> = .064) and tumor differentiation (<jats:italic>p<\/jats:italic> = .079).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This study demonstrates that both salvage pharyngectomy and primary surgery for advanced disease are viable options with high locoregional control. However, this represents a high\u2010risk group in terms of both operative morbidity and survival. Patients with nodal metastases, ECS, and poorly differentiated tumors are likely to succumb to their disease and should be selected for adjuvant therapy when possible. \u00a9 2006 Wiley Periodicals, Inc. Head Neck 28: 671\u2013677, 2006<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20428","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T18:03:49Z","timestamp":1148407429000},"page":"671-677","source":"Crossref","is-referenced-by-count":70,"title":["Primary and salvage (hypo)pharyngectomy: Analysis and outcome"],"prefix":"10.1002","volume":"28","author":[{"given":"Jonathan R.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Irish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Neligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Gullane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90315-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90146-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199708000-00001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70240-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<595::AID-HED2>3.0.CO;2-J"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310000683a"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10237"},{"key":"e_1_2_6_9_2","unstructured":"DeschlerDG.Pharyngoesophageal reconstruction: state of the art. 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