{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:06Z","timestamp":1786977786783,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:00:00Z","timestamp":1156377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>We describe a case of a 16\u2010year\u2010old white girl with Epstein\u2010Barr virus (EBV)\u2010positive nasopharyngeal carcinoma (NPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>At diagnosis, the patient had characteristic immunoglobulin (Ig)A and IgG responses to EBNA1, viral capsid antigen (VCA)\u2010p18, and early antigens (EAs), with no detectable EBV DNA in her blood. Combined chemotherapy and radiotherapy resulted in complete remission. Eighteen months later, the patient's IgA responses to EBNA1 and p18 and both IgA and IgG anti\u2010EA increased, without apparent recurrence. Five months later, lung metastases were found. She underwent surgical removal of the lung metastases and conventional chemotherapy, but had intraabdominal lymph node metastasis and mediastinal lesions develop. The patient was then treated with a novel treatment consisting of 5\u2010fluorouracil plus valproic acid and subsequent valganciclovir to induce lytic EBV replication. This resulted in the first detectable EBV DNA levels in the blood but did not result in clinical response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The patient's disease progressed, and the patient declined further cancer treatment and died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>In contrast to EBV DNA load, EBV serology was useful in predicting distant NPC metastasis after initial complete remission in this patient. \u00a9 2006 Wiley Periodicals, Inc. Head Neck, 2006<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.20466","type":"journal-article","created":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T18:58:38Z","timestamp":1156445918000},"page":"1040-1045","source":"Crossref","is-referenced-by-count":12,"title":["Epstein\u2010Barr virus (EBV) serology for predicting distant metastases in a white juvenile patient with nasopharyngeal carcinoma and no clinical response to EBV lytic induction therapy"],"prefix":"10.1002","volume":"28","author":[{"given":"Servi J. C.","family":"Stevens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Zwaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A. W. M.","family":"Verkuijlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap M.","family":"Middeldorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,24]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Globocan 2000, Cancer Incidence, Mortality and Prevalence Worldwide","author":"Ferlay J","year":"2001"},{"key":"e_1_2_5_3_2","first-page":"2346","article-title":"Nasopharyngeal carcinoma: epidemiology and treatment outcome","volume":"141","author":"Balm AJ","year":"1997","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_5_4_2","first-page":"3932","article-title":"Contrasted frequencies of p53 accumulation in the two age groups of North African nasopharyngeal carcinomas","volume":"10","author":"Khabir A","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970901)80:5<951::AID-CNCR18>3.0.CO;2-V"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)00956-2"},{"key":"e_1_2_5_7_2","series-title":"Monographs on the Evaluation of Carcinogenic Risks to Humans","volume-title":"Epstein\u2010Barr virus and Kaposi's sarcoma herpesvirus\/human herpesvirus 8","author":"IARC","year":"1997"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(02)00078-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/421245"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20310"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(96)80038-0"},{"key":"e_1_2_5_12_2","first-page":"15","article-title":"Quantitative detection of Epstein\u2010Barr virus DNA in clinical specimens by rapid real\u2010time PCR targeting a highly conserved region of EBNA\u20101","volume":"292","author":"Stevens SJ","year":"2005","journal-title":"Methods Mol Biol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.3986-3992.2002"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10213"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890400215"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.1.13"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.7.3066-3073.2005"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04058-6"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.178"},{"key":"e_1_2_5_20_2","unstructured":"JonesRJ KenneySC.Anti\u2010viral activity of statins\u2013a novel strategy for blockading lytic EBV replication. The 11th biennal conference of the international association for research on Epstein\u2010Barr virus and associated diseases. Regensburg Germany 20\u201325 September2004. Abstract 15.16."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303740200"},{"key":"e_1_2_5_22_2","first-page":"5781","article-title":"Activation of lytic Epstein\u2010Barr virus (EBV) infection by radiation and sodium butyrate in vitro and in vivo: a potential method for treating EBV\u2010positive malignancies","volume":"60","author":"Westphal EM","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_23_2","volume-title":"Epstein\u2010Barr Virus","author":"Israel BF","year":"2005"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:11:17Z","timestamp":1700007077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,24]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1002\/hed.20466"],"URL":"https:\/\/doi.org\/10.1002\/hed.20466","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,24]]}}}