{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:48:15Z","timestamp":1793785695710,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T00:00:00Z","timestamp":1163376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The assessment of the precise tumor extent of recurrent glottic carcinomas is a challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The histologic characteristics of 29 recurrent glottic carcinomas after radiation failures, initially classified as T1 and T2, were analyzed on whole\u2010organ slices. The growth patterns of 21 recurrent prT3 and prT4 and 52 primary pT3 and pT4 carcinomas were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen of 29 (52%) recurrent carcinomas were understaged by imaging studies and endoscopy. Most recurrent carcinomas presented with multicentric tumor foci, whereas most primary carcinomas with a concentric tumor growth pattern (<jats:italic>p<\/jats:italic> &lt; .05). Undifferentiated dissociated tumor cells were observed more often in the vicinity of recurrent tumor foci than of the primary tumor mass (<jats:italic>p<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recurrent glottic carcinomas are often understaged and present with multiple tumor foci dispersed in different regions of the larynx. If voice\u2010preserving salvage surgery is considered as a treatment option, these facts should be kept in mind. \u00a9 2006 Wiley Periodicals, Inc. Head Neck 2007<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20502","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:26:21Z","timestamp":1163463981000},"page":"26-32","source":"Crossref","is-referenced-by-count":89,"title":["Histologic characteristics and tumor spread of recurrent glottic carcinoma: Analysis on whole\u2010organ sections and comparison with tumor spread of primary glottic carcinomas"],"prefix":"10.1002","volume":"29","author":[{"given":"Peter","family":"Zb\u00e4ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Nuyens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Curschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Stauffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"4185","article-title":"Surgical management of irradiation failures in T1\u2010T2 squamous cell carcinoma of the glottic larynx","volume":"21","author":"Virtaniemi JA","year":"2001","journal-title":"Anticancer Res"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199605\/06)18:3<229::AID-HED4>3.0.CO;2-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80104-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.63"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10117"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<630::AID-HED9>3.0.CO;2-K"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880120409"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.8.705"},{"key":"e_1_2_5_10_2","volume-title":"UICC TNM classification of malignant tumors","author":"Sobin LH","year":"1997"},{"key":"e_1_2_5_11_2","volume-title":"TNM supplement: a commentary on uniform use","author":"Hermanek P","year":"1993"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.12.1473"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201014"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70274-1"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1263::AID-CNCR6>3.0.CO;2-J"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.194.3.7862960"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988609500215"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:56:49Z","timestamp":1700031409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,13]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/hed.20502"],"URL":"https:\/\/doi.org\/10.1002\/hed.20502","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,13]]}}}