{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:41:38Z","timestamp":1792172498971,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T00:00:00Z","timestamp":1169596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Factors that represent the potential for invasion and metastasis, such as matrix metalloproteinases (MMPs), could predict prognosis of cancer. Therefore, the authors studied plasma and tissue levels of MMP\u20102 and MMP\u20109 in oral cancer, the leading malignancy in India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Enzyme\u2010linked immunosorbent assay and gelatin zymography were used for the MMP analysis from plasma and tissue samples, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Latent, active, and total forms and activation ratio of MMP\u20102 and MMP\u20109 were significantly elevated in malignant tissues as compared with adjacent normal tissues. Activation of MMP\u20102 was higher than MMP\u20109 in malignant tissues. Activation ratio was significantly higher in malignant tissues of the patients with lymph node metastasis as compared with those without lymph node metastasis (<jats:italic>p<\/jats:italic> = .005). Plasma MMP\u20109 levels were significantly lower in responders as compared with pretreatment levels (<jats:italic>p<\/jats:italic> = .002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The data indicate that MMP\u20102 and MMP\u20109 can be useful to identify metastatic phenotype as well as for treatment monitoring in oral cancer. \u00a9 2007 Wiley Periodicals, Inc. Head Neck, 2007<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20561","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T05:34:01Z","timestamp":1169703241000},"page":"564-572","source":"Crossref","is-referenced-by-count":103,"title":["Clinical significance of MMP\u20102 and MMP\u20109 in patients with oral cancer"],"prefix":"10.1002","volume":"29","author":[{"given":"Beena P.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakuntala V.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin N.","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhudas S.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,24]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Burden and care of cancer patients, a consolidation report of six hospital cancer registries from 1984\u20131993 under the Indian Council of Medical Research","author":"National Cancer Registry Programme","year":"1996"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1999.tb00055.x"},{"key":"e_1_2_5_4_2","first-page":"2977","article-title":"Molescular aspect of oral cancer","volume":"22","author":"Nagler RM","year":"2002","journal-title":"Anticancer Res"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198704000-00056"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20010120)95:1<44::AID-IJC1008>3.0.CO;2-M"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/10454411930040020401","article-title":"Matrix metalloproteinases. 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