{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:41:42Z","timestamp":1760982102309},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T00:00:00Z","timestamp":1176249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Extent of neck dissection is controversial in patients with palpable medullary thyroid cancer (MTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We evaluated 64 MTC patients (19 hereditary, 45 sporadic) with palpable thyroid nodules (group 1, <jats:italic>n<\/jats:italic> = 35) or palpable lymph node metastases (group 2, <jats:italic>n<\/jats:italic> = 29). Standard surgery included total thyroidectomy, central compartment dissection, and additional neck dissection on indication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In group 1, 40% of the patients were cured. Thirty\u2010one percent of all patients had central, 23% ipsilateral, 14% contralateral, and 14% mediastinal, metastases. Fifty\u2010one percent developed locoregional recurrence. Locoregional recurrence (<jats:italic>p<\/jats:italic> = .043) and reoperations (<jats:italic>p<\/jats:italic> = .020) were noted more often after a less than standard initial procedure. In group 2, no patients were cured. All had central, 93% ipsilateral, 45% contralateral, and 52% mediastinal metastases. Thirty\u2010eight percent developed locoregional recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Locoregional recurrence frequently occurs in palpable MTC, and tumor control may be improved by standard central, bilateral, and upper mediastinal neck dissection. \u00a9 2007 Wiley Periodicals, Inc. Head Neck, 2007<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20609","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T22:16:45Z","timestamp":1176329805000},"page":"857-863","source":"Crossref","is-referenced-by-count":23,"title":["Locoregional control in patients with palpable medullary thyroid cancer: Results of standardized compartment\u2010oriented surgery"],"prefix":"10.1002","volume":"29","author":[{"given":"Jan Willem B.","family":"de Groot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thera P.","family":"Links","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem J.","family":"Sluiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce H. R.","family":"Wolffenbuttel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Wiggers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Th. M.","family":"Plukker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1995.5.407"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00136-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.12.011"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199010000-00002"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00392.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199706000-00011"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199911000-00013"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-000-0052-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02473391"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870180037007"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02160.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199906000-00016"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021713"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000415)88:8<1909::AID-CNCR21>3.0.CO;2-A"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(03)00408-2"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-001-0176-3"},{"key":"e_1_2_5_18_2","first-page":"60","article-title":"Reoperation in the treatment of asymptomatic metastasizing medullary thyroid carcinoma","volume":"99","author":"Tisell LE","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(95)90534-0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050203"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.8.895"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00333.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199809000-00005"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.118380a"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1996.6.305"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/10507250152741019"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:22:37Z","timestamp":1696868557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,11]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1002\/hed.20609"],"URL":"https:\/\/doi.org\/10.1002\/hed.20609","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,11]]}}}