{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:50:38Z","timestamp":1791078638397,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,5,17]],"date-time":"2007-05-17T00:00:00Z","timestamp":1179360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Laser cordectomy is gaining popularity for treatment of early glottic carcinoma, but little is known about vocal and quality of life (QOL) outcomes as a function of extent of resection. We prospectively examined QOL and vocal function of patients with carcinoma in situ (Tis) or T1 glottic carcinomas after laser cordectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic> = 75) were grouped into those who underwent unilateral subepithelial or subligamental resection (group A, <jats:italic>n<\/jats:italic> = 45); those who underwent unilateral transmuscular or total cordectomy (group B, <jats:italic>n<\/jats:italic> = 17); and those who underwent extended or bilateral cordectomy including the anterior commissure (group C, <jats:italic>n<\/jats:italic> = 19). The European Organization for Research and Treatment of Cancer head and neck cancer specific module (QLQ\u2010H&amp;N35), voice handicap index (VHI), and objective vocal function were examined before and 1 year after cordectomy and compared among the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>No major complications were encountered, but local recurrence occurred in 10 patients, with group C showing the highest rate (6\/19, 31.6%). Patient\u2010reported speech and social contact scores of QOL questionnaire and VHI scores after surgery were higher in groups B and C than in group A (<jats:italic>p<\/jats:italic> &lt; .05). The scores and perceptual and acoustic data were generally improved in all groups after surgery, but were statistically significant only in group A (<jats:italic>p<\/jats:italic> &lt; .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our data suggest that early glottic cancers with a limited extent and infiltration depth have improved outcomes, both oncologically and functionally, compared to those lesions requiring extensive laser resection. \u00a9 2007 Wiley Periodicals, Inc. 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