{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:26:38Z","timestamp":1776302798120,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T00:00:00Z","timestamp":1193702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Salivary ductal carcinoma (SDC) is an uncommon malignant tumor of the salivary glands. Although there is no known standard of care for the treatment of advanced disease, the vast majority of patients with SDC may be offered palliative systemic therapy. We report a case of epidermal growth factor receptor 2 (HER2)\u2010positive metastatic submandibular SDC with a complete and durable clinical response to treatment with trastuzumab in combination with chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A 62\u2010year\u2010old man was diagnosed with SDC of the left submandibular gland with extensive cervical lymph node involvement. The lesion was completely resected, and the patient underwent postoperative radiotherapy. After 6 months, multiple pulmonary metastatic lesions were detected. A complete response was reached with trastuzumab\u2010based combination therapy, and no evidence of disease progression has been observed after 14 months of initiation of systemic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Trastuzumab\u2010based combination therapies should be considered for advanced SDC. \u00a9 2007 Wiley Periodicals, Inc. Head Neck 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20714","type":"journal-article","created":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T20:56:44Z","timestamp":1193777804000},"page":"680-683","source":"Crossref","is-referenced-by-count":76,"title":["Successful treatment of pulmonary metastatic salivary ductal carcinoma with trastuzumab\u2010based therapy"],"prefix":"10.1002","volume":"30","author":[{"given":"Aleix","family":"Prat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Parera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Peralta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Cedr\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Huguet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep Maria","family":"del Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,30]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.3025"},{"key":"e_1_2_4_3_2","volume-title":"World Health Organization classification of tumours: pathology and genetics of head and neck tumours","author":"Barnes L","year":"2005"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199703)19:2<126::AID-HED7>3.0.CO;2-6"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980301386-X"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21116"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.6.951"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2470152"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203972"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.12.914"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0253"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00097-6"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20714","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T12:00:01Z","timestamp":1699963201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,30]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/hed.20714"],"URL":"https:\/\/doi.org\/10.1002\/hed.20714","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,30]]}}}