{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:45:37Z","timestamp":1759333537315},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T00:00:00Z","timestamp":1195430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATLL) is a highly aggressive T\u2010cell lymphoma and etiologically associated with human T\u2010lymphotropic virus type 1 (HTLV\u20101). Patients with ATLL commonly present with leukemic changes, systemic lymphadenopathy, and\/or extranodal lesion and have very poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results.<\/jats:title><jats:p>We describe a rare case of ATLL presenting as an isolated paranasal mass. Southern blot analysis of the biopsied specimens demonstrated multiple integration bands of HTLV\u20101 provirus of different intensities. Chemotherapy resulted in complete resolution of the paranasal mass. Thereafter, the patient showed an indolent clinical course with leukemic changes and pulmonary and cutaneous ATLL lesions and remains alive more than 5 years from diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>ATLL should be included in the differential diagnosis of sinonasal lymphoma, although the event is rare. Multiple HTLV\u20101 provirus integrations of different intensities may be indicative of good prognosis for ATLL. \u00a9 2007 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20730","type":"journal-article","created":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T23:46:59Z","timestamp":1195516019000},"page":"815-820","source":"Crossref","is-referenced-by-count":6,"title":["Adult T\u2010cell leukemia\/lymphoma with multiple integration of HTLV\u20101 provirus presenting as an isolated paranasal sinus tumor: A case report"],"prefix":"10.1002","volume":"30","author":[{"given":"Akitoshi","family":"Nagasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Shinhama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuo","family":"Kojya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Aonahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Yoshimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Takasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,13]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5149(03)00039-X"},{"key":"e_1_2_4_3_2","first-page":"338","article-title":"Lymphomas of the head and neck","volume":"26","author":"Yuen A","year":"1999","journal-title":"Semin Oncol"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900120068011"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00006"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200302000-00002"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0627-6"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208979"},{"key":"e_1_2_4_9_2","first-page":"200","volume-title":"Pathology and genetics of tumour of the hematopoietic and lymphoid tissue","author":"Kikuchi M","year":"2001"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc030003"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-16"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709068270"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00718623"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410301116"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980801)83:3<449::AID-CNCR13>3.0.CO;2-W"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<806::AID-CNCR26>3.0.CO;2-V"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950315)75:6<1281::AID-CNCR2820750610>3.0.CO;2-I"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(00)00094-8"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20015"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200009000-00015"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.10.011"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860240121037"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80520-8"},{"key":"e_1_2_4_24_2","first-page":"55","article-title":"Intracranial and orbital extension of a nasal cavity adult T\u2010cell leukemia: a case report","volume":"27","author":"Hayashi K","year":"1999","journal-title":"No Shinkei Geka"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198802000-00010"},{"key":"e_1_2_4_26_2","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood.V89.3.948","article-title":"Integration patterns of HTLV\u2010I provirus in relation to the clinical course of ATL: frequent clonal change at crisis from indolent disease","volume":"89","author":"Tsukasaki K","year":"1997","journal-title":"Blood"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2005.00698.x"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04242.x"}],"container-title":["Head &amp; 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