{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:32:46Z","timestamp":1790206366695,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T00:00:00Z","timestamp":1195430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>The benefit of a complementary fluorodeoxyglucose\u2010positron emission tomography (FDG\u2010PET) scan to standard workup for carcinoma of unknown primary (CUP) and metastatic neck lesions was prospectively studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Sixty\u2010seven patients underwent standardized diagnostic workup according to national guidelines including panendoscopies, multiple mucosal biopsies, and diagnostic CT\/MRI scans. Median follow\u2010up was 40 months (range, 2\u201365 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In 60 eligible patients, FDG\u2010PET indicated a primary tumor or metastatic disease in 30 patients (50%). Additional investigations confirmed a primary tumor in 18 patients: hypopharynx in 5, oropharynx in 5, nasopharynx in 2, lung in 1, axilla in 1, bone in 1, rectum in 1, as well as multiple metastatic lesions from CUP in 2 patients. In retrospect, MRI was able to detect 1 of the PET\u2010detected primaries, leading to an overall detection rate of PET of 29% in CUP. A therapeutic change of treatment was made in 25% as a consequence of FDG\u2010PET. PET before panendoscopy demonstrated fewer false\u2010positive pathological foci.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>FDG\u2010PET is a valuable tool in addition to conventional extensive workup in CUP and neck metastases. Consequently, FDG\u2010PET is now recommended as an early diagnostic modality in the workup of these patients. \u00a9 2007 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20734","type":"journal-article","created":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T23:46:37Z","timestamp":1195515997000},"page":"471-478","source":"Crossref","is-referenced-by-count":151,"title":["Prospective study of 18FDG\u2010PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA\u201013 study"],"prefix":"10.1002","volume":"30","author":[{"given":"J\u00f8rgen","family":"Johansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Buus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Loft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Keiding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Overgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Sand","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Grau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Bundgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Kirkegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Overgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980315)82:6<1160::AID-CNCR22>3.0.CO;2-3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00007"},{"key":"e_1_2_5_4_2","first-page":"816","article-title":"FDG PET detection of unknown primary tumors","volume":"41","author":"Bohuslavizki KH","year":"2000","journal-title":"J Nucl Med"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.104807"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00018"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10191"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0819-0"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20687"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00172-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20462"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14361-9"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-1078-9"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.7.626"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2003.07.006"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01462-6"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00037-X"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2341031554"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860500423948"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.20734","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.20734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T20:53:52Z","timestamp":1696798432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.20734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,19]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/hed.20734"],"URL":"https:\/\/doi.org\/10.1002\/hed.20734","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,19]]}}}