{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:18:14Z","timestamp":1763036294650},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T00:00:00Z","timestamp":1203379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our aim was to determine the incidence of local control in patients with selected squamous carcinoma of the vallecula treated with horizontal supraglottic laryngectomy; to analyze the consequences of local recurrence in terms of nodal recurrence, distant metastasis, survival, causes of death, overall local control, and laryngeal preservation; and to identify any clinical factors predictive of these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective nonrandomized case series in a university teaching hospital. An inception cohort of 95 previously untreated patients were followed until death or for a minimum of 5 years. According to the 2002 Union Internationale Contre le Cancer (UICC) staging classification system, the tumor was classified as T1, T2, and T3 in 13, 60, and 22 patients, respectively, while disease in 67 patients was considered to be in stages III to IV. All patients underwent a horizontal partial supraglottic partial laryngectomy. Ninety\u2010four patients had an associated neck dissection. An induction chemotherapy regimen was used in 91 patients; postoperative radiation therapy was given for 49 patients. The main outcome measures were local recurrence, nodal recurrence, distant metastasis, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 1\u2010, 3\u2010, and the 5\u2010year actuarial survival estimates were 86.3%, 64.2%, and 47.4%, respectively. Overall, the main causes of death were as follows: metachronous second primary tumor (47.2% of patients), intercurrent disease (16.7%), distant metastasis (15.3%), local recurrence (6.3%), and nodal recurrence, (4.2%). The 1\u2010, 3\u2010, and 5\u2010year actuarial local recurrence rates were 4.5%, 11%, and 11%, respectively. Nine patients developed a local recurrence; 3 were successfully salvaged. Using multivariate analysis, no single variable was found to increase the risk for local recurrence. The overall laryngeal preservation rate and local control rate were 89.5% (85\/95) and 93.4% (89\/95), respectively. Local recurrence was associated with a significant increase in nodal recurrence (<jats:italic>p<\/jats:italic> &lt;.04) and distant metastasis (<jats:italic>p<\/jats:italic> = .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on this experience, horizontal partial supraglottic laryngectomy appears to be a valid approach for functional organ\u2010preservation in patients with selected T1\u2013T3 SCC of the vallecula. \u00a9 2008 Wiley Periodicals, Inc. Head Neck, 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.20780","type":"journal-article","created":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T18:16:50Z","timestamp":1203445010000},"page":"756-764","source":"Crossref","is-referenced-by-count":6,"title":["Horizontal supraglottic partial laryngectomy for selected squamous carcinoma of the vallecula"],"prefix":"10.1002","volume":"30","author":[{"given":"Laurent","family":"Laccourreye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Brasnu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ollivier","family":"Laccourreye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Christopher","family":"Holsinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195806000-00002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100066032"},{"key":"e_1_2_6_4_2","first-page":"87","article-title":"Etude analytique de 65 cancers de la vall\u00e9cule trait\u00e9s chirurgicalement","volume":"95","author":"Andr\u00e9 P","year":"1978","journal-title":"Ann Otolaryng Paris"},{"key":"e_1_2_6_5_2","first-page":"119","article-title":"Les cancers de la vall\u00e9cule: indications th\u00e9rapeutiques et r\u00e9sultats","volume":"95","author":"Colonna d'Istria J","year":"1978","journal-title":"Ann Otolaryngol Paris"},{"key":"e_1_2_6_6_2","first-page":"133","article-title":"Traitement chirurgical des cancers de la vall\u00e9cule. 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